Human blood plasma proteins: structure and function

Human Blood Plasma Proteins provides an overview of human blood plasma proteins with special emphasis on their structure and function and, if known, also in relation to pathological states and diseases. The various systems in blood plasma like blood coagulation and fibrinolysis, the complement system, the immune defense system, the transport and storage systems, and many other systems with proteins as key players are discussed in detail. Special emphasis is placed on the structural/functional relationship of blood plasma proteins and the unique features of the many, mainly multidomain proteins in human blood plasma.Wherever possible, the authors establish links from the systematic understanding of blood proteins to the use of protein databases, to help the reader follow new developments and to make good use of the possibilities these databases offer. INDICE: Contents Part I Introduction Blood Components Introduction Short History Blood Components Blood Cells Blood Plasma The Blood Group System References Blood Plasma Proteins Introduction Short History Classification of Blood Plasma Proteins References Part II Domains, Motifs and Repeats Introduction The Epidermal Growth Factor-like (EGF-like) Domain The Kringle Domain The g-carboxyglutamic Acid-rich (Gla) Domain The PAN/Apple Domain The Sushi/CCP/SCR Domain The Fibronectin type-I, the Fibronectin type-II Collagen-binding and the Fibronectin type-III Domains The Coagulation Factors 5/8 type C Domain (FA58C) The Thrombospondin type I Repeat (TSP1) The VWFA, VWFC and VWFD Domains The Cystatin-like Domain The LDL-receptor class A (LDLRA) and class B (LDLRB) DomainsThe C-Terminal Cystine Knot (CTCK) Structure The Anaphylatoxin Domain The CUBDomain The NTR Domain The C-type Lectin (CTL) Domain The Ig-like Domain References (General) Protein Families Introduction Serine Proteases: The Trypsin Family Serine Protease Inhibitors (Serpins) The a2-Macroglobulin Family The Serum Albumin Family The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature The Kazal Serine Protease Inhibitors Family Signature The Multicopper Oxidase Family The Lipocalin Family The Globin Family The Glucagon / Gastric Inhibitory Polypeptide (GIP) / Secretin / Vasoactive Intestinal Peptide (VIP) Family The Glycoprotein Hormone Family Membrane Attack Complex Components / Perforin Signature (The Complement C6/C7/C8/C9 Family) The Lipase Family Hormone Families and Signatures The Erythropoietin / Thrombopoietin Signature The Corticotropin-releasing Factor Family The Gonadotropin-releasing Hormone Signature The Calcitonin / CGRP / IAPP Family The Gastrin / Cholecystokinin Family The Insulin Family Growth Factor Families The platelet-derived Growth Factor Family The Transforming Growth Factor-b Family Cytokine Families The Tumor Necrosis Factor Family The Interferon a, b and d Family Interleukin Families and Signatures The Interleukin-1 Signature The Interleukin-2 Signature The Interleukin-4 / -13 Signature The Interleukin-6 / Granulocyte Colony-stimulating Factor / Myelomonocytic Growth Factor Family The Interleukin-7 and 9 Signature Interleukin-10 Family The Small Cytokine (Intercrine / Chemokine) Family and Signature Posttranslational Modifications Introduction Databases for posttranslational modifications (PTMs) Disulphide Bridges Glycosylation Phosphorylation Ser / Thr Phosphorylation Sites Tyr Phosphorylation Site Hydroxylation Aspartic Acid and Asparagine Hydroxylation Site Sulphation Acylation and Alkylation Amidation Carboxylation Crosslinks The Isoglutamyl Cysteine Thioester Bond The Isopeptide Bond Part III Blood Coagulation and Fibrinolysis Introduction Primary Haemostasis TheCoagulation Cascade The Fibrinolytic System The Regulation of Blood Coagulation and Fibrinolysis The Kinin and Angiotensin / Renin System References The Complement System Introduction The Classical Pathway The Alternative Pathway TheTerminal Components of the Complement System Components of Complement Activation Regulation of the Complement System References The Immune System Introduction Immunoglobulins Antibody Diversity Major Histocompatibility Complex (MHC) Proteins Innate Immune System Other Proteins References Enzymes Introduction EC 1: Oxidoreductases EC 1.11: Peroxidases EC 2: Transferases EC 2.3: Acyltransferases EC 2.6: Transfer of nitrogenous group EC 2.7: Transfer of phosphorous-containing groups EC 3: Hydrolases EC 3.1: Esterases (ester bond) EC 3.2: Glycosylases (sugars) EC 3.4: Peptidases (peptide bonds) EC 3.4.17: Metallocarboxypeptidases EC 3.4.21: Serine endopeptidases (serine proteases) EC 3.4.22: Cysteine endopeptidases (cysteine proteases) EC 3.4.23: Aspartic endopeptidases (aspartic proteases) EC 5: Isomerases EC 5.3: Oxidoreductases (intramolecular) Inhibitors Introduction Serine Protease Inhibitors (Serpins) Introduction Structural Properties Inhibitory Reaction Blood Coagulation and Fibrinolysis Blood Coagulation Fibrinolysis The Complement System General Inhibitors Other Serpins Other Inhibitors References Lipoproteins Introduction Enzymes in LipoproteinMetabolism Apolipoproteins LDL and VLDL Receptors Serum Amyloid A Proteins References Hormones Introduction Pancreatic Hormones Gastrointestinal Hormones Calcium Metabolism Hormone Releasing Factors, their Trophic Hormones and Related Hormones Vasopressin and Oxytocin Natural Opioid Peptides Vasoactive Peptides Erythropoietin and Thrombopoietin Others Adiponectin Islet Amyloid Polypeptide References Cytokines and Growth Factors Introduction Interleukin Families The Interleukin-1 Family Interleukin-2 Family Interleukin-3 Family Interleukin-4 / Interleukin-13 Family Interleukin-5 Family Interleukin-6 Family Interleukin-7 / Interleukin-9 Family Interleukin-10 family Interleukin-15 Family Granulocyte-macrophage Colony-stimulating Factor Family Tumor Necrosis Factor Family The Interferon Family The a- / b-interferon family The g-interferon family Chemokines The intercrine-a / chemokine CxC family The intercrine-b / chemokine CC family The Platelet-derived Growth Factor / Vascular Endothelial Growth Factor Family Transforming Growth Factor-b Family Miscellaneous The nerve growth factor-b family Epidermal Growth Factor Insulin-like Growth Factor Binding Proteins References Transport and Storage Introduction The Serum Albumin Family The Globin Family Haptoglobin Iron Transport and Storage Iron Oxidation: Ceruloplasmin Iron transport Proteins: Transferrins Iron Storage Heme Transport and Iron Recovery: Hemopexin Transport of Hormones, Steroids and Vitamins Hormone Transport Proteins Steroid Transport Proteins Vitamin A Transport Protein OtherTransport Proteins in Plasma Selenoproteins References Additional Proteins Introduction Additional Blood Plasma Proteins

• ISBN: 978-0-470-01674-9
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 512
• Fecha Publicación: 21/03/2008
• Nº Volúmenes: 1
• Idioma: Inglés