Advances in cancer stem cell biology

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumortypes. Cancer stem cells or 'cancer cell like stem cells' have been isolated from various cancers of different origin (blood, breast, brain, skin, head andneck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stemcells. Identifies a molecular phenotype for modified stem cells. Looks into the first challenge of molecular oncology. Gives insight into pathogenetic mechanisms at the basis of cancer stem cells. INDICE: Preface.- Cancer Stem cell. A revisitation of “anaplasia” concept.Stem cells and cancer stem cells- new insights. Molecular biology of cancer stem cells. Biomarkers of cancer stem cells. Cancer stem cell and the microenvironment. Leukemia stem cells. Cancer stem cell and the central nervous system.Cancer stem cells and glioblastoma multiforme. Pathophysiological and clinical aspects. Breast cancer stem cells. Colon cancer stem cells. Liver Tumor-Initiating Cells. Cancer Stem Cells: Past Studies, Current Status and Future Perspectives. Pancreatic cancer stem cells. Cancer stem cell and renal carcinoma. Cancer stem cells. Proteomic approaches for new potential diagnostic and prognostic biomarkers. Cancer stem cells. An innovative therapeutic approach. Cancerstem cell and ATP binding cassette. Which role in chemoresistance?. Stem celland cancer stem cells. Biological and clinical interrelationships. Cancer stem cell and antitumor immunity. Index

• ISBN: 978-1-4614-0808-6
• Editorial: Springer New York
• Encuadernacion: Cartoné
• Páginas: 388
• Fecha Publicación: 28/11/2011
• Nº Volúmenes: 1
• Idioma: Inglés