Studies on cardiovascular disorders

This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signalling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signalling pathways in cardiovascular development during embryogenesis—and what impact these might have in the differentiation process of resident cardiac and blastocyst-derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medicalpractitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system. Cutting-edge research Leading scientists in the field INDICE: Preface Contributor’s List Chapters: 1) The evolving concept of oxidative stress 2) Mechanisms of redox signaling in cardiovascular disease 3) Reactive oxygen and nitrogen species in cardiovascular differentiation of stem cells 4) Reactive Oxygen Species (ROS) and the sensory neurovascular component5) Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Post-Conditioning 6) Coenzyme Q9/Q10 and Healthy Heart 7) Oxidative and proteolytic stress in homocysteine associated cardiovascular diseases 8) Functional studies of NADPH oxidases in human vasculature 9) Relationship of the CYBA gene polymorphisms with oxidative stress and cardiovascular risk 10) Redox-related genetic markers of cardiovascular diseases 11) NADPH oxidases and blood-brain barrier dysfunction in stroke 12) Smoking-Induced Oxidative Stress in the Pathogenesis ofCardiovascular Diseases 13) Oxidative Stress in Vascular Aging 14) Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus 15) Reactive Oxygen Species, Oxidative Stress and Hypertension 16) Peripartum cardiomyopathy: Role ofSTAT-3 and reactive oxygen species 17) Oxidative stress and inflammation after coronary angiography 18) Oxidative Stress in Cardiac Transplantation 19) Oxidative Stress and Atrial Fibrillation 20) Oxidative stress and the anti-oxidative capacity in myocardial infarction 21) Oxidative Stress and Redox Signalling in Cardiac Remodelling 22) Oxidative Stress and Cardiovascular Fibrosis 23) Oxidative Risk Factors for Cardiovascular Disease in Women 24) Protective effects of food on cardiovascular diseases 25) Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications 26) Thioredoxin in the cardiovascular system – towards a thioredoxin-based anti-oxidative therapy27) The protective effect of melatonin on the heart 28) Exercise Induced cardioprotection: Overview with an emphasis on the role of anti-oxidants 29) Antioxidative properties of statins in the heart

• ISBN: 978-1-60761-599-6
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 1250
• Fecha Publicación: 29/09/2010
• Nº Volúmenes: 1
• Idioma: Inglés