Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer's disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out. Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology Presents content that is clear and easy to read Useful for researchers and instructors in many fields INDICE: 1. Antioxidants as modulators of the Ubiquitin-proteasome system against aging and proteinopathies2. Modulation of oxidative stress by S-nitrosation and other thiol modifications3. Regulation of Nrf2 Signaling Pathway and the Hallmarks of Aging: An Overview4. Fluid redox biomarkers in neurological disease5. CCM proteins are key players in redox signaling and oxidative stress regulation in Cerebral6. Effects of maternal and early life nutrition on redox homeostasis7. Mitochondria-associated membranes (MAMs) as modulators of oxidative stress in Alzheimer's disease8. Oxidative stress biomarkers in human health and disease9. Modulation of the antioxidant defense system against pathophysiological redox imbalance in cardiovascular diseases10. Modulation of cancer cell proliferation by interfering with metabolic ROS production11. Modulation of human hydrogen sulfide metabolism by physiological effectors12. Intestinal redox and Inflammatory Bowel Disease13. Applications of Plant-Derived Products in Photodynamic Therapy14. Hopes and disappointments related to the use of flavonoids in therapeutical approaches15. Omega-3 nutritional intervention as therapeutic coadjuvant approach to improve Rett Syndrome clinical and biochemical features16. A glance on antioxidants: the role of sulfur amino acids in retinal disorders17. Oxidative stress and antioxidant-based therapies in couple infertility18. Modulation of oxidative stress in psoriasis: Pathophysiology and therapy

• ISBN: 978-0-443-19247-0
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 306
• Fecha Publicación: 07/08/2023
• Nº Volúmenes: 1
• Idioma: Inglés