Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI. Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments. Provides a comprehensive resource for novel approaches and treatments that improve function and quality of life for individuals with CNP/SCIIncludes contributors from the private sector and academiaCovers epidemiology of chronic pain following SCI, experimental models, mechanisms of chronic pain in SCI, and new targets and technologies INDICE: Part I: Epidemiology of Chronic Pain Following SCI 1. Central neuropathic pain (CNP)-Risk factors and symptom-based classification 2. Other chronic pain syndromes following SCI: Musculoskeletal and visceral pain 3. Physiological changes following SCI that impact on pain 4. SCI/D in children and adolescents 5. Pressure ulcers 6. Musculoskeletal changes after SCI including secondary spine deformities, spondyloarthropathies and heterotopic ossification 7. SCI in the presence of traumatic brain injury 8. Clinical considerations following SCI that impact on pain Part II: Experimental Models of CNP/SCI 9. Models and Mechanisms 10. Challenges of developing animal models of CNP 11. Evaluating evoked withdrawal in CNP 12. Evaluation of spontaneous pain in animal models of SCI 13. Operant tasks to explore the affective dimension of CNP Part III: Mechanisms of CNP following SCI 14. Overview 15. Peripheral mechanisms and targets 16. Spinal mechanisms and targets 17. Supraspinal mechanisms and targets 18. Inflammation Post SCI: Gut to Increased Gain in Pain 19. Channelopathies Contribute to Neuropathic Pain after SCI 20. Alterations in PNS Contribute to Neuropathic Pain after SCI 21. Lipid Peroxidation and Contributions to Neuropathic Pain after SCI Part IV: New Targets and Technologies 22. Neural Stem for Neuropathic Pain Relief after SCI 23. Stem Cells as a Source for Myelination and Attenuation of Neuropathic Pain 24. Transplants for Attenuation of Neuropathic Pain after SCI 25. Contributions of Mechanisms in Skin to Neuropathic Pain 26. Microglia Activation and Neuropathic Pain 27. Glial Activation and Neuropathic Pain 28. Role of Intraspinal Sprouting of Primary Afferents 29. Aggressive Rehabilitation Attenuates Neuropathic Pain 30. Imaging SCI Neuropathic Pain 31. Biomarkers of SCI Neuropathic Pain
- ISBN: 978-0-12-818662-6
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 500
- Fecha Publicación: 01/05/2021
- Nº Volúmenes: 1
- Idioma: Inglés