A growing body of evidence highlights the importance of intrinsically disordered proteins (IDPs) and regions (IDRs) in fundamental cellular functions and biochemical processes. Increasing evidence associates alterations in the expression levels or activity of IDPs with human pathologies; and, in recent years, researchers have placed stronger emphasis on developing computational and experimental approaches to describe binding of IDPs to their functional targets, and establish drug designs for new therapeutics acting on IDPs and IDRs. Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of IDPs and IDRs, including signaling, binding, and regulation, with methodology for study and associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in-depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. In addition, leading researchers in the field of IDPs and IDRs contribute chapters on IDP approaches little explored to-date, such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Provides in-depth discussions on fundamental IDP and IDR dynamics, function, and binding, along with mechanistic insights that support new drug developmentDescribes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targetsFeatures chapter contributions from international experts in IDP and IDR biochemical function and methods of study INDICE: 1. Introduction to Intrinsically Disordered Proteins and Regions Part I: Methods for the characterization of dynamics and binding of IDPs 2. Ensemble descriptions of IDPs and IDRs: integrating simulation and experiment 3. Experimental characterization of the dynamics of IDPs and IDRs by NMR 4. Single-molecule studies of IDPs and IDRs Part II: Models and mechanisms of IDP and IDR binding 5. Experimental studies of IDP binding 6. Computational models of IDP binding Part III: Biological and medical implications of IDP binding 7. IDPs and IDRs in membraneless organelles 8. Molecular mechanisms of fibrillation of IDPs 9. Perspectives on drug-discovery strategies based on IDPs 10. Conclusion and future directions
- ISBN: 978-0-12-816348-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 328
- Fecha Publicación: 01/07/2019
- Nº Volúmenes: 1
- Idioma: Inglés