Alzheimers Disease Research Guide: Animal Models for Understanding Mechanisms and Medications

Alzheimer's Disease Research Guide: Animal Models for Understanding Mechanisms and Medications provides researchers with a comprehensive guide, detailing every aspect of Alzheimer's Disease research, including chapters on neuroinflammation, immunotherapy, biomarkers, and animal modeling. This book begins with historical perspectives of both pathological chronology and pathological biochemistry in relation to Alzheimer’s disease. Other chapters review Amyloidogenic AB and Non-Amyloidogenic tau and Metabolism of AB major components to the research and understanding of Alzheimer’s research. The book concludes with specific treatment chapters including how to develop safe, effective, and inexpensive medications and the application of genome editing to the treatment of Familial Alzheimer's Disease.Written by world renowned expert in Alzheimer’s research, this book is a valuable resource for all researchers. Reviews why familial Alzheimer’s disease is vital to understanding sporadic Alzheimer’s diseaseDescribes the latest “game changer” animal models of Alzheimer's disease and frontotemporal dementia in detailExplains how various Alzheimer’s disease medications have failed clinical trialsDiscusses pros and cons of therapeutic antibodies, lecanemab and donanemab, that were recently found to be effective in recent clinical trialsDetails the application of genome editing as a treatment for familial Alzheimer’s diseaseProposes publishing “Journal of Negative Data” for the days of generative AI-assisted publication, AI being unable to distinguish between reproducible and unreproducible data, particularly important in Alzheimer’s research INDICE: 1. Introduction: Collaboration and Competition Together to Maximize the Velocity of Research and Development2. Pathological Chronology and Pathological Biochemistry: The Beginning of The Beginning3. Human Genetics: Establishment of Cause-And-Effect Relationships4. Two Major Culprits: Amyloidogenic Aß And Non-Amyloidogenic Tau5. Exact relationship between Aß40 and Aß426. Metabolism of Aß: Catabolic and glimphatic systems7. Biology of time: Temporal distance between cause and effect8. 1st generation animal moßdels of Aß amyoloidosis: Pros and cons of overexpression paradigm9. Creation of single APPKNOCK-IN mouse models and of single MAPTNOKCK-IN models: Demonstration of AB-Tau axis10. Application of Mouse Models to the experimental studies of AD11. Neuroinflammation: Microgliosis and Astrocytosis in the days of microscopic omics12. Central and peripheral nervous system, immune systems and digestive system: AD as a systemic disorder13. Failure of more than 400 candidate medications in clinical trials before 202014. Therapeutic antibodies as a Wright brothers' airplane: Clinical proof-of-concept15. Biomarkers for presymptomatic diagnosis and prognosis16. Targeting somatostatin receptor heterodimer for developing safe, effective and ineffective and inexpensive medications17. Application of genome editing to the treatment of familial AD18. Identifying significant and insignificant publications: Prelude for chapter XIX19. Journal of negative data for the days of generative AI-assisted publication20. Conclusions

• ISBN: 978-0-443-28979-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/08/2024
• Nº Volúmenes: 1
• Idioma: Inglés