A comprehensive and authoritative compilation of up–to–date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up–to–date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government INDICE: List of contributors .Preface .Acknowledgements .PART I .1. Introduction Sara C. Sahu .2. Application of Stem cells and iPS cells in Toxicology Maria Virginia Caballero, Ramon Espinoza Lewis and Manila Candiracci .3. Stem cells: A potential source for high throughput screening in toxicology Harish K Handral, Gopu Sriram and Tong Cao .4. Human pluripotent stem cells for toxicological screening Du Lili and Chen Dunjin .5. Effects of culture conditions on maturation of stem cell–derived cardiomyocytes Deborah K. Hansen, Amy L. Inselman and Xi Yang .6. Human stem cell–derived cardiomyocyte in vitro models for cardiotoxicity screening Tracy Walker, Kate Harris, Evie Maifoshie, Khuram Chaudhary .7. Disease Specific Stem Cell Models for Toxicological Screenings and Drug Development Matthias Jung, Juliane Susanne Jung, Jovita Schiller and Insa S. Schroeder .8. Three–dimensional culture systems and humanized liver models using hepatic stem cells for enhanced toxicity assessment Ran–Ran Zhang, Yun–Wen Zheng, Hideki Taniguch) .9. Utilization of in vitro neurotoxicity models in pre–clinical toxicity assessment Karin Staflin, Dinah Misner, and Donna Dambach .10. A human stem cell model for creating placental syncytiotrophoblast, the major cellular barrier that limits fetal exposure to xenobiotics R. Michael Roberts, Shinichiro Yabe, Ying Yang, and Toshihiko Ezashi .11. Effects of Endocrine Disruptors on Mesenchymal Stem Cells Marjorie Bateman, Amy Strong, John McLachlan, Matthew Burow, Bruce Bunnell .12. Epigenetic Landscape in Embryonic Stem Cells Xiaonan Sun, Nicholas Spellmon, Joshua Holcomb, Wen Xue, Chunying Li and Zhe Yang .PART II .13. The Effect of Human Pluripotent Stem Cell Platforms on Preclinical Drug Development Kevin G. Chen .14. Generation and application of 3D culture systems in human drug discovery and medicine Rashidi H and Hay DC .15. Characterization and therapeutic uses of adult mesenchymal stem cells Julian Kiang .16. Stem Cell Therapeutics for Cardiovascular Diseases Yuning Hou, Xiaoqing Guan, Shukkur M. Farooq, Xiaonan Sun, Peijun Wang, Zhe Yang, and Chunying Li .17. Stem cell–based therapies for vascular regeneration in peripheral artery diseases David Smadia and Jean–Sebastien Silvestre .18. Gene modified stem/progenitor cell therapy for ischemic stroke Yaning Li, Guo–Yuan Yang, and Yongting Wang .19. Role of stem cells in the gastrointestinal tract and in the development of cancer Pengyu Huang, Bin Li, Yun–Wen Zheng) .20. Cancer stem cells: Concept, significance and management Haseeb Zubair, Shafquat Azim, Sanjeev Srivastava, Arun Bhardwaj, Saravanakumar Marimuthu, Mary Patton, Seema Singh, Ajay Singh .21. Stem cell signaling in the heterogenous development of medulloblastoma Joanna Triscott and Sandra Dunn .22. Induced pluripotent stem cell–derived ocular blood–retinal barrier for disease modeling and drug discovery Jun Jeon, Nathan Hotaling, Kapil Bharti .23. Important considerations in the therapeutic application of stem cells in bone healing and regeneration Hoda Elkhenany, Shawn Bourdo, Alexandru Biris, David Anderson and Madhu Dhar .24. Stem cells from human dental tissue for regenerative medicine Junjun Liu and Shangfeng Liu .25. Stem cells in the skin Hongwei Wang, Zhonglan Su, Shiyu Song, Ting Su , Mengyuan Niu, Yaqi Sun, Hui Xu .Index
- ISBN: 978-1-119-13541-8
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 608
- Fecha Publicación: 13/01/2017
- Nº Volúmenes: 1
- Idioma: Inglés