Molecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence. Covering universal themes in aging, such as the exhaustion of stem cells and subsequent loss of the regenerative refueling of organs as well as immunosenescence, this text illuminates new directions for research not yet explored in the still poorly investigated area of molecular mechanisms of lung aging. The molecular nature of general aging processes is explored with targeted coverage on how to analyze lung aging through experimental approaches. INDICE: Section 1: Mechanisms of Aging This section covers principal molecular aspects of organismal aging and cellular senescence and seeks to give an overview on known cellular pathways of aging. The topics will be mainly covered by basic scientists who are experts in the field of molecular aging pathways but will also give an overview on mechanisms of senescence in the lung. Chapter 1: Telomerase Function in Aging Calado RT (National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. [email protected]) Chapter 2: Immunosenescence in Infection (mainly focusing on CD8T cell responses) Blackman MA (SourceTrudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA. [email protected]) Or : Age–related changes in immune function: effect on airway inflammation. Busse PJ (Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. [email protected]) Chapter 3: Oxidants and metabolism Finkel T (Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA, [email protected]) Chapter 4: Protein quality control in aging Meiners S (Comprehensive Penumology Center, Helmholtz Center Munich, Max–Lebsche Platz 31, 81377 Munich, Germany, silke.meiners@helmholtz–muechen.de) Chapter 5: Signaling networks in aging Brunet A (Department of Genetics, Stanford University, CA 94305, USA, [email protected]) Chapter 6: Senescence in the lung Lesaux Jordan C (Division of Cardiology, UT Health Science Center, San Antonio, MC 7872, USA, [email protected]) Section 2: How to investigate aging in the lung This shorter section will give an overview on the available animal models for aging and on studying gene expression. It also reviews analysis of lung function in mice models of age–related lung diseases. Chapter 7: Mouse models to study aging Richardson A (Department of Cellular and Structural Biology, Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA. [email protected]) Chapter 8: Profiling candidates of aging George A. Garinis (Institute of Molecular Biology and Biotechnology, FORTH, Vassilika Vouton, P.O.Box 1385, GR 711 10 Heraklion, Crete, Greece) Chapter 9: Use of animal models to explore lung aging Neptune ER (Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, [email protected]) Section 3: The aging lung This section will give an overview on the development and on the physiological aging of the lung. It will also cover lung diseases that have been associated with premature aging of the lung. Chapter 10: Development and physiological aging of the lung Pinkerton KE (Center for Health and the Environment, University of California, Davis, California 95616, USA, [email protected]) Chapter 11: Premature aging of the damaged infant lung Filippone M or Baraldi E (E. Baraldi, Dept of Paediatrics, Via Giustiniani 3, 35128 Padova, Italy, E–mail: [email protected]) (Chapter 12: Age–related alterations in lung cancer Malcolm C. Pike ??? He is at the Memorial Sloan–Kettering http://www.mskcc.org/news/magazine/july–2009/malcolm–c–pike–joins–msk–epidemiology–service) Chapter 13: Premature aging in IPF Rojas M (Interstitial Lung Diseases at the Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15213; [email protected]) Chapter 14: Lung infections and aging Meyer KC (Department of Medicine, K4/930 Clinical Sciences Center, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792–9988, USA. [email protected]) Chapter 14: COPD as a disease of premature aging Serge Adnot (INSERM U955, Hôpital Henri Mondor, AP–HP, Créteil, France, [email protected]) Chapter 15: Demography of Aging David E. Bloom Harvard University (http://www.hsph.harvard.edu/pgda/)
- ISBN: 978-1-118-39624-7
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 232
- Fecha Publicación: 16/04/2014
- Nº Volúmenes: 1
- Idioma: Inglés