Algebraic and Combinatorial Computational Biology

Algebraic and Combinatorial Computational Biology

Robeva, Raina
Macauley, Matthew

96,71 €(IVA inc.)

Algebraic and Combinatorial Computational Biology introduces students and researchers to a panorama of powerful and current methods for mathematical problem-solving in modern computational biology. Presented in a modular format, each topic introduces the biological foundations of the field, covers specialized mathematical theory, and concludes by highlighting connections with ongoing research, particularly open questions. The work addresses problems from signaling, gene regulation, genomics, RNA folding, infectious disease dynamics, drug resistance modeling, phylogenetics, neuroscience, and ecological networks. Supporting online supplements are provided to aid instruction and provide practical experience with the material. Integrates a comprehensive selection of tools from computational biology into education or research programsEmphasizes practical problem-solving through multiple exercises, projects and spinoff computational simulationsContains scalable material for graduate classes and project useSupported by illustrative datasets and adaptable MATLAB computer code INDICE: 1. DNA nanostructures: Mathematical design and problem encoding 2. Understanding DNA rearrangements: Graphs and polynomials 3. Multi-scale graph-theoretic modeling of bimolecular structures 4. Toward revealing protein function: Identifying biologically relevant clusters with graph spectral methods 5. Multistationarity in biochemical networks: Results, analysis, and examples 6. Regulation of gene expression by operons: Boolean, logical, and local models 7. Modeling the stochastic nature of gene regulation: probabilistic Boolean networks 8. Inferring interactions in molecular networks via primary decompositions of monomial ideals 9. Analysis of combinatorial neural codes: an algebraic approach 10. Predicting neural network dynamics: insights from graph theory 11. Clustering via self-organizing maps on biology and medicine 12. Optimization problems in phylogenetics: Polytopes, programming and interpretation 13. The relative accuracy of SVDquartets on simulated data with varying model conditions: connecting algebraic statistics to data analysis

  • ISBN: 978-0-12-814066-6
  • Editorial: Academic Press
  • Encuadernacion: Rústica
  • Páginas: 300
  • Fecha Publicación: 01/08/2018
  • Nº Volúmenes: 1
  • Idioma: Inglés