Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Gives an introduction on neuroimmunological diseases, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Proves changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases INDICE: 1. Introduction on neuroimmunology2. Neuroimmune interactions: from bench to bedside3. Role of neural-immune dysregulation in the periphery in the development of immune dysfunctions4. Autoimmune and autoinflammatory neurologic disorders5. The role of GM-CSF in neuroimmune diseases6. Epstein-Barr virus and neuroinflammation7. Immunopathology of multiple sclerosis8. The impact of epigenetic dynamics in multiple sclerosis9. Biomarkers of multiple sclerosis10. Cytotoxic cells in multiple sclerosis: new targets for treatment11. Antibodies and antibody fragments developed for treatment of multiple sclerosis12. Microbiome and multiple sclerosis13. Immune responses to parasites and herpesviruses in people with multiple sclerosis - potential applications for prevention and treatment14. Translational research to develop spingosine-1-phosphate receptor modulator therapies for multiple sclerosis15. Innate and adaptive immunomodulation by burton tyrosine kinase (BTK) inhibitors: review of emerging multiple sclerosis treatment16. Neuroimmunology of fatigue in multiple sclerosis17. Neuroinflammation and sleep18. Glioma: restoring innate immunity to improve adaptive immune cell therapy19. Pericytes, a cell type contributing to the immunological tolerance during Glioblastoma20. Immunological Aspects of Glaucomatous Optic Neuropathy Etiology and Treatments21. Translational neuroimmunology; lessons from non-human primates22. Neuroimmunology: translational lessons from zebrafish
- ISBN: 978-0-323-85841-0
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 316
- Fecha Publicación: 01/03/2023
- Nº Volúmenes: 1
- Idioma: Inglés