Glioblastoma: molecular mechanisms of pathogenesis and current therapeutic strategies

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field. INDICE: Overview of the Molecular Genetics and Molecular Chemotherapy of GBM.- Primary Brain Tumors: Characteristics, Practical Diagnostic, and Treatment Approaches.- Pathology of Glioblastoma Multiforme.- Molecular Mechanisms of Pathogenesis in Glioblastoma and Current Therapeutic Strategies.- Aberrant Signaling Complexes in GBMs: Prognostic and Therapeutic Implications.- Role of Aberrant Cell Cycle in the Growth and Pathogenesis of Glioblastoma.- Adult Neural Stem Cells and Gliomagenesis.- Divide and Invade: The Dynamic Cytoskeleton of Glioblastoma Cells.- Aberrations of the Epigenome in Gliomas: Novel Targets for Therapy.- Chemotherapy for Glioblastoma: Past, Present, and Future.- Role of Angiogenesis in the Pathogenesis of Glioblastoma and Anti-angiogenic Therapies for Controlling Glioblastoma.- Anti-angiogenic Strategies for the Treatment of Gliomas.- Retinoids for the Treatment of Glioblastoma.- Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas.- Current Endeavors for Enhancing Efficacy of Paclitaxel for Treatment of Glioblastoma.- Dietary Polyphenols as Preventive and Therapeutic Agents in Glioblastoma.- Targeting Energy Metabolism in Brain Cancer with Calorically Restricted Diets.- Immunotherapy for Glioblastoma.- Potential of Nanobiotechnology in Management of Glioblastoma Multiforme.

• ISBN: 978-1-4419-0409-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 374
• Fecha Publicación: 01/09/2009
• Nº Volúmenes: 1
• Idioma: Inglés