Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates

Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates presents the most recent synthetic methodologies in carbohydrate chemistry from an international team of experts. The volume focuses on the development of inhibitors, vaccines and antimicrobials with novel modes of action. An introduction with relevant background to synthetic glycoconjugate vaccines is included, with a focus on synthetic carbohydrate-base vaccines licensed or under development. This book is ideal for researchers working as synthetic organic chemists, as well as conjugation and protein chemists, immunologists, and microbiologists in academia and industry. Emphasizes structural and biosynthetic similarities and shows synthetic approaches to ulosonic acidsCovers biologically relevant glycans and glycoconjugates, as well as glycoconjugate synthesisProvides information for the development of inhibitors, vaccines and antimicrobials INDICE: I. Advances in chemical synthesis and biosynthesis of bacterial glycans 1. Prokaryotes: Sweet proteins do matter 2. Glycan ligation reactions in the periplasmic space 3. Synthesis of bioactive lipid A and analogues 4. Synthesis of lipopolysaccharide core fragments 5. Synthesis of oligosaccharides related to potential bioterrorist pathogens 6. Teichoic acid chemistry for vaccine applications 7. NMR characterization of bacterial glycans and glycoconjugate vaccines II. Synthetic carbohydrate-based vaccines: present and future 8. Glycoconjugate vaccines, production and characterization 9. Antifungal glycoconjugate vaccines 10. Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development 11. Glyconanoparticles as versatile platforms for vaccine development

• ISBN: 978-0-12-820954-7
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/02/2020
• Nº Volúmenes: 1
• Idioma: Inglés