Recent Trends in Carbohydrate Chemistry: Biomedical and Material Science Applications

Recent Advances in Carbohydrate Chemistry: Biomedical and Materials Science Applications presents the most recent synthetic methodologies in carbohydrate chemistry. The book emphasizes structural and biosynthetic similarities and distinct differences among sugar acids to provide the background information needed for the development of inhibitors, vaccines and antimicrobials with novel modes of action. Lastly, polysaccharides, which are commonly modified chemically to attain new properties are examined. An introduction and relevant background to synthetic glycoconjugate vaccines is included, with a focus on synthetic carbohydrate-base vaccines licensed or under development. The work is ideal for researchers working as synthetic organic chemists, as well as conjugation and protein chemists, immunologists and microbiologists-in both academia or industry. Demonstrates the importance of carbohydrate chemistry for the access of carbohydrate-based natural moleculesCovers monosaccharide syntheses and transformations towards biologically active small molecular entities and glycomimeticsEmphasizes structural and biosynthetic similarities and shows synthetic approaches to ulosonic acidsProvides information on the development of inhibitors, vaccines and antimicrobials Presents the most recent findings on polysaccharide synthesis and bioapplications, such as carbohydrate-based vaccines INDICE: I. Monosaccharide chemistry toward molecular diversity--Recent findings 1. Perspective on the transformation of carbohydrates under green and sustainable reaction conditions 2. Hydroxymethylfurfural (HMF) and Glucosyloxymethylfurfural (GMF) in Multi-Component Reactions 3. Alkynedicobalt complexes in carbohydrates: Synthetic applications 4. Molecular Diversity Through Gold-catalysis on Saccharide Building Blocks 5. Glycomimetics with unnatural glycosidic linkages 6. Synthetic Approaches to Functionalized Oxepanes and Azapanes from Monosaccharides 7. N- and C-Glycopyranosyl Heterocycles as Glycogen Phosphorylase Inhibitors 8. Recent developments in synthetic methods for sugar phosphates, phosphonates and analogous P-containing compounds II. Advances in chemical synthesis and biosynthesis of bacterial glycans 9. Prokaryotes: Sweet proteins do matter 10. Glycan ligation reactions in the periplasmic space 11. Synthesis of bioactive lipid A and analogues 12. Synthesis of lipopolysaccharide core fragments 13. Synthesis of oligosaccharides related to potential bioterrorist pathogens 14. Techoic acid chemistry for vaccine applications 15. NMR characterization of bacterial glycans and glycoconjugate vaccines III. Structure-function relationships in polysaccharides 16. Polysaccharides: chemical synthesis 17. Linear and cyclic amylose, beyond natural 18. Modification of xanthan in the ordered and disordered states 19. Derivatized polysaccharides on silica and hybridized with silica in chromatography and separation - a mini review IV. Synthetic carbohydrate-based vaccines: present and future 20. Glycoconjugate vaccines, production and characterization 21. Antifungal glycoconjugate vaccines 22. Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development 23. Glyconanoparticles as versatile platforms for vaccine development

• ISBN: 978-0-12-817467-8
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/10/2019
• Nº Volúmenes: 1
• Idioma: Inglés