Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they?re generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology. INDICE: 1. Cancer Stem Cells – From Identification To Isolation Evolution of Cancer Stem Cell Concept V.K. Rajasekhar and Piero Dalerba MSKCC Epiblast/Germ Line/ Trophoblastic theory of cancer development Mariusz Z. Ratajczak Epithelial Metaplasia–neoplastic transformation Philippe Delvenne Chromothrepsis–Role in Cancer and stem Cells Peter Campbell Cell of Origin in Cancers Jane E Visvader Tumor heterogeneity and correlation to cancer stem cell content Piero Paolo Di Fiore Hypoxic gradients and stem cell distribution and role in cancers Francesca Pistollato Critique on cancer stem cells Brent A Reynolds and M. Rahman Brent Methods in cancer stem cells V. K. Rajasekhar and Malcolm Moore 2. Stemness and Cancer stroma Cancer stem cells and Microenvironment Pradip Roy–Burman Reciprocal activation of cancer cells and cancer stroma–stimulation of stemness Paola Chiarugi 3. Cancer stem cells in organ cancers AML Craig Jordon and Christopher Park Basal Cell Carcinoma K. Sellheyer Bladder Cancer N.P. Mongan Cornell Medical School Brain Cancer Jeremy Rich Breast Cancer Michael Clarke Chronic Myeloid Leukemia Michael Deininger and Brian Druker Colon Cancer John Dick Gastric Cancer Deborah Gumucio Leukemia John E. Dick Lung Cancer Carla Kim Ovarian cancer Malcolm Moore Prostate cancer Owen Witte and Michael Shen 4. Reprogramming and Cancer Stem Cells Cancer stem cell generation in vitro Paola Scaffidi Reprogramming of cancer cells Jia–Lin Lee Factors in reprogramming of cancer cells Masaki Mori and Hideshi Ishii Sarcoma /Breast/Prostate Igor Matushansky Met Paolo M. Comoglio and Livio Trusolino Nanog DG. Tang Oct4 Jianwu Dai MYC M. C. Simon BMI–1 Owen Witte LGR5 Masaki Mori 5. Clinical Relevance and Minimal Residual Disease Oncogene relevance in cancer stem cells Isido Sanchez–Garcia Garcia Rationale and Strategies of therapeutic targeting of Cancer stem cells Ruggero De Matia Stem cells as emerging platform for antibody therapy Karen Aboody and Richard Frank Mesenchymal stem cells–Chemotherapy resistence Emile Voest Stem Cells and therapeutic guidance in cancers Emile Voest Acute Myeloid Leukemia Rajendra Majeti Breast Cancer Max Wicha and Gabriella Dontu University of Michigan Chronic Myeloid Leukemia (CML) Michael Deininger and Brian Druker Colorectal Cancer Eduard Batlle del(5q) Myelodysplasia Sten Eirik Jacobsen Prostate Cancer V.K. Rajasekhar Pediatric Brain Cancer Richard Gilbertson Rectal Cancer Markus Frank
- ISBN: 978-1-118-35616-6
- Editorial: Wiley–Blackwell
- Encuadernacion: Rústica
- Páginas: 552
- Fecha Publicación: 10/03/2014
- Nº Volúmenes: 1
- Idioma: Inglés