Mitochondrial Medicine: A Guide for Health Care Providers and Translational Researchers

Mitochondrial Medicine: A Primer for Healthcare Providers and Translational Researchers is an applied, holistic resource addressing the evolving and multidisciplinary area of mitochondrial disease. In twenty-six short, easily accessible chapters, Dr. Prasun Pankaj discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis, and treatment of mitochondrial diseases. Three all-inclusive sections examine the role of mitochondria in common medical conditions such as diabetes and heart failure, and the full range of inherited mitochondrial diseases, covering the genetic and biochemical basis of both mitochondrial DNA deletion syndromes and point mutation syndromes, their clinical presentation, treatment plans, genetic counseling, prenatal testing, and ongoing research of translational relevance. While providing a solid foundation in its topic area, each chapter in Mitochondrial Medicine is written in an accessible format with illustrative case studies, making for a quick reference at the patient's bedside or clinical laboratory. Includes a basic introduction to mitochondria and their misfunctions in human diseasePresents current practice and research in mitochondrial medicine, with emphasis on clinical presentation, diagnosis, treatment, genetic counseling, and prenatal testingFeatures short, accessible chapters with illustrative case studies for quick reference at the patient's bedside or in the clinical laboratoryProvides thorough coverage of inherited mitochondrial disorders, as well as the role of mitochondria in common medical conditions INDICE: Section 1: Basics of mitochondrial medicine 1. Functions of mitochondria 2. Clinical presentation of mitochondrial diseases 3. Mitochondrial genetics 4. Diagnosis of mitochondrial diseases 5. Treatment of mitochondrial diseases 6. Genetic counseling, prenatal diagnosis, and reproductive options of mitochondrial diseases Section 2: Inherited mitochondrial diseases Mitochondrial DNA deletion syndromes 7. Kearns-Sayre syndrome 8. Pearson syndrome 9. Progressive external ophthalmoplegia Mitochondrial DNA point mutation syndromes 10. MELAS 11. MERRF 12. LHON 13. Mitochondrial DNA associated Leigh and NARP syndromes 14. MIDD Section 3: Mitochondrial disease of nuclear origin Mitochondrial DNA depletion syndrome 15. POLG related disorders 16. MPV17 17. DGUOK 18. MNGIE 19. Disorders of mitochondrial translation 20. Disorders of mitochondrial fission and fusion Mitochondria and common medical conditions 21. Mitochondria and aging 22. Mitochondria and diabetes 23. Mitochondria in obesity and metabolic syndrome 24. Mitochondria and heart disease 25. Mitochondria in neurodegenerative diseases 26. Mitochondria and cancer

• ISBN: 978-0-12-817006-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 364
• Fecha Publicación: 01/06/2019
• Nº Volúmenes: 1
• Idioma: Inglés