Fetal and neonatal physiology: expert consult - online and print

The new 3rd Edition of Fetal and Neonatal Physiology is today's most encyclopedic, in-depth compendium of knowledge on the normal and abnormal physiology of the foetus and neonate. Over 270 international authorities detail the uniquecharacteristics that distinguish foetal and neonatal physiology from the physiology of adults - and, where appropriate, address the pathophysiology and clinical management of selected neonatal diseases. ÍNDICE: I. Genetics: GeneticsII. Embryology: Embryology. Regulation of Embryogenesis. Pathophysiology of Congenital MalformationsIII. The Placenta: Placental Development. Regulation of the Placental Circulation. Mechanisms of Transfer Across the Human Placenta. Endocrine and Paracrine Function of the Human Placenta. Placental Proteins. Placental Separation at Birth. Multiple PregnancyIV. Developmental Pharmacology and Pharmacokinetics: Basic Pharmacologic Principles. Basic Pharmacokinetic Principles. Physiochemical and Structural Properties Regulating Placental Drug Transfer. Genetic Regulation of Drug Metabolism. Drug Distribution During Fetal Life. Drug Protein Binding During Development. Development of Renal Excretion of Drugs During Ontogeny. Pharmacodynamics and Receptor Sensitivity During Development. Drug Abuse During Fetal and Neonatal Life. Sympathoadrenal Mechanisms During Development. Developmental Neuropharmacology. Physiologic Differences of Clinical Significance. Therapeutic Drug Monitoring in the Newborn. Drug Excretion during LactationV.Intrauterine Growth: Intrauterine Growth and NutritionVI. Postnatal Growth and Nutrition: Infant Growth in the First Year of Life. Endocrine and Other Factors Affecting Growth. Water Requirements. Energy Requirements. Protein Requirements. Carbohydrate Requirements. Fat Metabolism and Requirements. Mineral and Trace Element Requirements. Vitamin Requirements. Human Milk Composition and Function in the Infant. Types and Methods of Feeding for Infants. Nutritional Assessment. Growth Outcome of Critically Ill NeonatesVII. Perinatal Iron, Trace Minerals, and Vitamin Metabolism: Iron Metabolism during Fetal and Neonatal Life. Trace Element Metabolism in the Fetus and Neonate. Metabolism of Vitamin A and Water SolubleVitamins During Fetal and Neonatal Life. Vitamin E Metabolism in the Fetus and Neonate. Vitamin K Metabolism during the Fetal and Neonatal PeriodsVIII. Lipid Metabolism in the Fetus and Newborn: Placental Transport of Free Fatty Acids, Glycerol, and Ketone Bodies. Lipid Accretion in the Fetus and Newborn. Brown Adipose Tissue: Development and Function. Lipids and an Energy Source for the Premature and Full-Term Neonate. Ketone Body Production and Metabolism in the Fetus and Newborn. Very Long Chain Fatty Acids in the Developing Retina and Brain. Physiological Effects of Lipid Infusions. Developmental Physiology of Lipoproteins and Cholesterol. Lipoprotein LipaseIX. Carbohydrate Metabolism: Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn. Maternal Metabolism During Pregnancy. Carbohydrate Metabolism in the Fetus. Role of Glucoregulatory Hormones on Hepatic Glucose Metabolism During the PerinatalPeriod. Cell Glucose Transport and Glucose Handling During Fetal and NeonatalDevelopment. Glucose Metabolism During the Transition to Postnatal Life. Hypoglycemia and Hyperglycemia in the NewbornX. Protein Metabolism: General Concepts of Protein Metabolism. Fetal Requirements and Placental Transfer of Nitrogenous Compounds. Nitrogen Sources for the Newborn. Protein Metabolism in the Newborn. Protein and Amino Acid Requirements. Modification of Protein MetabolismBecause of DiseaseXI. Thermoregulation: Perinatal Thermal Physiology. Neonatal Thermal Physiology. Physics and Physiology of Human Incubation. Temperature Measurement in the Preterm Newborn. Incubator ManagementXII. Skin: Structural and Biochemical Organogenesis of Skin and Cutaneous Appendages in the Fetus and Newborn. Development of the Cutaneous Circulation. Composition of Skin Lipids. Sweating in the Neonate. pH Patterns in Newborn Skin. Skin Barrier Function. Bacterial Colonization of the Skin of the NewbornXIII. Fetal and Neonatal Cardiovascular Physiology: Development of the Fetal Heart. Molecular Developmentof the Heart. Role of Peptide Growth Factors in Cardiovascular Development. Fetal and Neonatal Cardiovascular Physiologic Development. Developmental Electrophysiology in the Fetus and Neonate. Developmental Biology of the Pulmonary Vasculature. Development of the Pulmonary Circulation: Metabolic Aspects. Development of the Gastrointestinal Circulation in the Fetus and Newborn. Regulation of the Fetal Cerebral Circulation. Autonomic and Central Neuroregulation of Fetal Cardiovascular Function. Endocrine Regulation of the Fetal Circulation. Nitric Oxide and the Perinatal Circulation. Regulation of Umbilical Blood Flow. Fetal and Placental Circulation During Labor. Cardiovascular Diagnosis in the Fetus and the Effects of Congenital Heart Lesions on Developing Physiology. Response of the Fetal Circulation to Stress. Fetal and Neonatal Congestive Heart Failure. Physiology of ResuscitationXIV. The Lung: Normal and Abnormal Structural Development of the Lung. Fetal and Neonatal Lung-liquid Balance. Functional Development of the Upper Airway. Functional Development of the Lower Airway. Functional Development of Respiratory Muscles. Mechanics of Breathing. Pulmonary Gas Exchange in the Developing Lung. Oxygen Transport and Delivery. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate. Pathophysiology of Apnea of Prematurity. Evaluation of Pulmonary Functionin the Neonate. Pathophysiology of Hyaline Membrane Disease (Excluding Surfactant). Pathophysiology of Lung Injury and Repair: Special Features of the Immature Lung. Pathophysiology of Chronic Lung Disease. Physiologic Effects of Conventional Mechanical Ventilation. Physiology of High Frequency Ventilation. Liquid Ventilation. Physiology of Extracorporeal Membrane OxygenationXV. Pulmonary Surfactant: Historical Perspective. Composition of Pulmonary Surfactant Lipids and Proteins. Biophysical Activities of Pulmonary Surfactant. Lung Morphogenesis: Formation and Function of the Alveolar Surface Layer. Regulation of Surfactant-associated Phospholipid Synthesis and Secretion. Pathophysiology of Respiratory Distress Syndrome. Hormonal Therapy for Prevention of Respiratory Distress Syndrome. Surfactant Replacement TherapyXVI. Physiology Of The Gastrointestinal Tract in the Fetus and Neonate: Cellular and Molecular Aspects of Human Gastrointestinal Development. Organogenesis, Innervation, and Histologic Development of the Gastrointestinal Tract. Development of the Enteric Nervous System. Development of Gastric Secretory Function. Development of Intestinal and Colonic Motility. Motility of the Upper Gastrointestinal Tract in the Fetus and Neonate. Development of Exocrine Pancreatic Function. Digestive and Absorptive Function in the Fetus and Infant. Pathophysiology of Gastroesophageal Reflux. Pathophysiology and Epidemiology of Necrotizing EnterocolitisXVII. Liver and Bilirubin Metabolism: Organogenesis and Histologic Development of the Liver. Fetal and Postnatal Hepatic Vasculature and Blood Flow. Bile Acid Metabolism during Development. Bile Secretion and its Control in the Mature and Immature Organism. Hepatic Disposition of Xenobiotics during Prenatal and Early Postnatal Development. Bilirubin Metabolism and Toxicity in the Newborn. Pathophysiology of Breast-Milk Jaundice. Phototherapy for Neonatal Jaundice. Pathophysiology of Metabolic Diseases of the Liver. Pathogenesis of Neonatal Cholestasis.Evaluation of Liver FunctionXVIII. The Kidney: Embryogenesis and Anatomic Development of the Kidney. Renal Function in Utero. Postnatal Maturation of RenalBlood Flow. Development of the Renin-Angiotensin System. Postnatal Development of Glomerular Filtration. Measurement of Glomerular Filtration Rate in Neonates. Renal Transport of Sodium During Early Development. Potassium Transport in Early Development. Transport of Calcium and Phosphorus. Transport of Amino Acids During Early Development. Developmental Aspects of Organic Acid Transport. Concentration of the Urine. Dilution of the Urine. Urinary Acidification. The Response to Nephron Loss in Early Development. Regulation of Blood Pressure During Fetal and Newborn Life. Clinical Significance of Developmental Renal Physiology. Pathophysiology of Acute Renal Failure in the Neonatal Period. Continuous Hemofiltration in NeonatesXIX. Fluid and Electrolyte Metabolism: Fluid Distribution in the Fetus and Neonate. Fetal and neonatal Body Fluid Composition with Reference to Growth and Development. Colloid Pressure and Osmoregulation in the Pregnant Woman, Fetus, and Neonate. Regulation of Acid-Base Balance in the Fetus and Neonate. Hydrops Fetalis and Other Causes of Neonatal Edema and AscitesXX. Hematopoiesis and Granulopoiesis: Developmental Biology of the Hematopoietic Growth Factors. Developmental Granulopoiesis. Developmental Erythropoiesis. Developmental MegakaryocytopoiesisXXI. Hemostasis: Normal Hemostasisin the Newborn: Plasmatic Factors. Normal Hemostasis in the Newborn: CellularFactors, Platelets, and the Vessel Wall. Pathophysiology of Bleeding Disorders in the Newborn. Pathophysiology of Neonatal Disseminated Intravascular Coagulation and ThrombosisXXII. Developmental Immunobiology: Host Defense Mechanisms Against Bacteria, Fungi, Viruses, and Nonviral Intracellular Pathogens. T-Cell Development. B-Cell Development. Mononuclear Phagocyte System. Neutrophil Function in Newborn Infants. The Complement System in the Fetus and Newborn. Cytokines and the Inflammatory Response. Integrins and Cell Adhesion Molecules. Stimulus-Response Coupling. Fetal and Neonatal Wound Healing. Immunology of the Breast and Host Immunity. Amniotic Fluid Host Defense Mechanisms. Host Defense Mechanisms in the LungXXIII. Neurology: Development of the Nervous System. Development of the Blood-Brain Barrier. Development of Neurotransmitters. Biochemistry of Hypoxic-ischemic Brain Injury. Perinatal Brain Metabolism and Prevention of Asphyxial Injury. Developmental Biochemistry: Studies in vivo with Nuclear Magnetic Resonance Spectroscopy. Electroencephalography in the Premature and Full-term Infant. Development of Tone and Reflexes in the Fetus and Newborn. Cerebral Blo

• ISBN: 978-1-4160-3479-7
• Editorial: Saunders
• Encuadernacion: Cartoné
• Páginas: 2208
• Fecha Publicación: 03/11/2011
• Nº Volúmenes: 2
• Idioma: Inglés