BetaSys: systems biology of regulated exocytosis in pancreatic ß-Cells

BetaSys uses the example of regulated exocytosis in pancreatic ß-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology,its methods and applications. This book uses the example of regulated exocytosis in pancreatic ?-cells, and it’s relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications In using a focused approach here by picking one outlook, the topic of Systems Biology is moreaccessible Systems Biology is a fast moving field, but the work presented here emphasizes the principal aspects of the field, making this a tool for on-going research INDICE: Preface.- Systems Biology of the Beta-cell - Revisited.- Established facts and open questions of regulated exocytosis in ?-cells – a background for a focused systems analysis approach.- Mitochondria and metabolic signals in ?-cells.- Beta cell ontogenesis and the insulin production apparatus.- The Mathematical Microscope Making the inaccessible accessible.- Megnetic ResonanceImaging of Pancreatic Beta Cells.- Mapping The ?-Cell In 3D At The Nanoscale Using Novel Cellular Electron Tomography And Computational Approaches.- In vivo Applications of Inorganic Nanoparticles.- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality.- The role of the cytoskeleton in transport and release of insulin-containing granules by pancreatic beta-cells.- Bioimpedance Spectroscopy.- DNA variations, impaired insulin secretion and type 2 diabetes.- Genetically programmed defects in beta-cell function.- Proteomic analysis of the pancreatic islet ?-cell secretory granule: current understanding and future opportunities.- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin).- Present state of islet transplantation for type-1 diabetes patients.- Predictive protein networks and identification of drugable targets in the beta-cell.- Nanotoxicity.- From silicon cell to silicon human.- Probing Cellular Dynamics with Mesoscopic Simulations.-What drives calcium oscillations in beta-cells? New tasks for cyclic analysis.- Whole-body and cellular models of glucose-stimulated insulin secretion.- Geometric and Electromagnetic Aspects of Fusion Pore Making.- Index.

• ISBN: 978-1-4419-6955-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 440
• Fecha Publicación: 12/11/2010
• Nº Volúmenes: 1
• Idioma: Inglés