Handbook of Synthetic Organic Chemistry, Second Edition, updates and expands the author's popular 2007 work, Synthetic Organic Chemist's Companion. The new Handbook provides valuable, practical guidance; incorporates corrections; and includes coverage on important topics such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions. The book maintains the useful organization of the author's earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis: from reagents, solvents, and temperature control to documentation, implementation, purification, and analytical methods for the product. From planning and setting up reactions to recording them in the Research Notebook and in articles, Handbook of Synthetic Organic Chemistry provides insight and valuable guidance into every step of the process. Practical information for every part of the process with engaging real-world examplesUseful guidance for conducting literature searches, handling and preparing reagents, working up the reaction, and identifying the productValuable coverage of conventional and microwave temperature control; paper and electronic research notebooks; eluent selection; Schlenk lines; purification methods and determination; chiral chromatography; chemical safety, and more INDICE: 1. Safety2. Searching the literature3. Reagents4. Gases5. Reactions on a small scale -- 1-25 mmol6. Temperature control7. Solvents8. The research notebook9. Conducting the reaction itself10. Following the reaction11. Working up reactions12. Evaporation13. Vacuum systems14. Purification of products15. Methods for structure elucidation16. Cleaning up after the reaction17. Specific examples18. Strategies for reaction optimizationAppendices1. Safety protocols2. Synthetic solvent selection chart3. Solvent miscibility4. Freezing points of common organic solvents5. Toxicities of common organic solvents6. Recipes for TLC stains7. NMR spectral data of common contaminants of organic and organometallic reaction products8. Acidities of organic functional groups9. Acidities of organic functional groups in DMSO10. Stuck joints
- ISBN: 978-0-12-809581-2
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 284
- Fecha Publicación: 01/09/2016
- Nº Volúmenes: 1
- Idioma: Inglés