Cancer and IgE: introducing the concept of allergooncology

The first volume based on the field named 'AllergoOncology' The term 'AllergoOncology', recently created by Dr. Jensen-Jarolim, aims to reveal the functionof IgE-mediated immune responses against tumor cells in order to enhance the understanding of its biology and develop novel treatment options based on IgE against malignant diseases INDICE: Introduction.- The biology of IgE: molecular mechanism restrainingpotentially dangerous high serum IgE titres in vivo.-The biology of IgE: the generation of high affinity IgE antibodies.- Epidemiological evidence: IgE, atopy and aolid tumors.- Epidemiological evidence: IgE, allergies, and hematopoietic malignancies.- Mast cells in allergy and tumor disease.- The IgE antibodyand its use in cancer immunotherapy.- IgE interacts with potent effector cells against tumors: ADCC and ADCP.- IgE as adjuvant in tumor vaccination.- The targets of IgE: allergen-associated and tumor-associated molecular patterns (AAMPs and TAMPs).- The role of Th2-mediated anti-tumor immunity in tumor surveillance and clearance.

• ISBN: 978-1-60761-450-0
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 210
• Fecha Publicación: 01/12/2009
• Nº Volúmenes: 1
• Idioma: Inglés