Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications

Developmental Biology and Musculoskeletal Tissue Engineering focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches to their work.  It highlights how this combined approach can lead to the promise of positive clinical outcomes.  Written as a source of information for both those within the field and those with a nascent interest, it provides background information on the relevant areas of developmental biology and state of the art solutions and/or technologies. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative research and eventual enhanced clinical outcomesInitial chapters provide an outline of the development of the musculoskeletal system in general, and in particular the tissues described in later chaptersAddresses the effect of mechanical forces on the musculoskeletal system during its  development the relevance of same to tissue engineeringDiscusses the importance of genes for the development of musculoskeletal tissues and their potential use in tissue engineeringDescribes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, Meniscus, disc, tendon and muscle repair INDICE: 1. Developmental biology of musculoskeletal tissues for Tissue Engineers2. The Mechanics of Musculoskeletal Development3. HOX genes in musculoskeletal development4. Developmental and orthopaedic diseases5. Synovial joint development6. Articular and Growth plate Cartilage development7. Bone development8. Meniscus development9. Disc development10. Tendon development11. Muscle development12. Biomimetic tissue engineering based on human development13. Clinical translation

• ISBN: 9780128114674
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 18/05/2018
• Nº Volúmenes: 1
• Idioma: Inglés