Development and engineering of dopamine neurons

The chapters presented in this book provide an overview of the different stages that are distinguished during mdDA neuronal development. Chapter 1 discusses the dopamine systems of the zebrafish, being a powerful model organism for genetic intervention on the developmental programming of neuronal systems. In Chapter 2 an overview is presented of dopamine systems that are present in the vertebrate CNS. Chapters 3-6 discuss the early specification of dopamine precursors and the programs that lead to terminal differentiation. In Chapters 7 and 8 the maintenance of dopamine neurons is discussed with a special emphasis on neurotrophic support. The specific connectivity of the dopamine system and the axon guidance rules that apply to developing dopamine neurons are describedin Chapter 9. An overview of ES-cell engineering of dopamine neurons is presented in Chapters 10 and 11. INDICE: 1. Development of the Dopamine Systems in Zebrafish.- 2. Dopamine Systems in the Forebrain.- 3. The Role of Otx genes in Progenitor Domains of Ventral Midbrain.- 4. Terminal Differentiation of Mesodiencephalic DopaminergicNeurons: the role of Nurr1 and Pitx3.- 5. Foxa1 and Foxa2 Transcription Factors Regulate Differentiation of Midbrain Dopaminergic Neurons.- 6. Transcriptional Regulation of their Survival: The Engrailed Homeobox Genes.- 7. Neurotrophic Support of Midbrain Dopaminergic Neurons.- 8. TGF-ß in Dopamine Neuron Development, Maintenance and Neuroprotection.- 9. Axon Guidance in the Dopamine System.- 10. Protocols for Generating ES Cell-Derived Dopamine Neurons.- 11. Molecular and Cellular Determinants for Generating ES-Cell Derived Dopamine Neurons for Cell Therapy.

• ISBN: 978-1-4419-0321-1
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 145
• Fecha Publicación: 01/06/2009
• Nº Volúmenes: 1
• Idioma: Inglés