Clinical epidemiology provides the scientific basis for the practice of medicine due to its focus on the diagnosis, prognosis and management of human disease through the study of research design, measurement and evaluation. In Clinical Epidemiology: Practice and Methods, leading experts contribute selections intended to educate researchers on how best to undertake clinical research. Divided into two categories, the volume first covers issues of design, measurement and analysis associated with various research designs, then continues with methods to better inform medical decision-making, including aggregation of multiple studies using meta-analysis, health economics, clinical practice guidelines and health technology assessment. Presents the basic science of practicing physicians and allied health professionals Focuses on determination of diagnosis, prognosis and management of human disease Outlines the concepts and methods of patient-related research, with an emphasis on research design, measurement and evaluation INDICE: On framing the research question and choosing the appropriate research design.- Longitudinal studies and determination of risk.- Modeling longitudinal data I: principles of multivariate analysis.- Modeling longitudinal data II: standard regression models and extensions.- The design of randomized controlled trials.- Analysis of randomized controlled clinical trials.- Evaluation of diagnostic tests.- Biomarkers and surrogates in clinical studies.- Measurement and analysis of patient-reported outcomes.- Bias in clinical studies of genetic diseases.- Genetic Epidemiology of Complex Phenotypes.- Qualitative research in clinical epidemiology.- Primer on Systematic Review and Meta-analysis.- The role of health economics within clinical research.- Development and limitations of clinical practice guidelines.- Basics of Health Technology Assessment.- Research Ethics for clinical researchers.- Budgeting, funding and managing clinical research projects.
- ISBN: 978-1-58829-964-2
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 305
- Fecha Publicación: 01/09/2008
- Nº Volúmenes: 1
- Idioma: Inglés