This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been capturedby a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker '? the first time that coarse-grained modelling has been applied to dynamicDNA nanotechnology. INDICE: A Novel DNA Model.- Methods.- Finite Size Effects.- Structural andMechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.
- ISBN: 978-3-642-30516-0
- Editorial: Springer
- Encuadernacion: Cartoné
- Fecha Publicación: 31/08/2012
- Nº Volúmenes: 1
- Idioma: Inglés