In Nuclear Receptors as Drug Targets, authors from leading pharma companies present examples and real-life data from their work. The text systematically covers drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR, and LXR, making this text a valuable tool for medicinal chemists, pharmaceutical industry, biochemists, molecular biologists, and pharmacologists. INDICE: Nuclear Receptors as Modern Drug Targets - a Historic Perspective Targeting the Nuclear Receptor - Cofactor Interaction Untangling the Estrogen Receptor Web Subtype Selective Estrogens Estrogen Receptors as Therapeutic Targets in Breast Cancer Progesterone Receptor and Progestines Progesterone Receptor Antagonists Nonsteroidal Tissue Selective Androgen Receptor Modulators TheGlucocorticoid Receptor as Target for Classic and Novel Anti-inflammatory Therapy and Novel Glucocorticoid Receptor Ligands Vitamin D Analogs as Modulatorsof Vitamin D Receptor Action PPARs: Therapeutic Targets for Metabolic Diseaseand Type 2 Diabetes Retinoids in Clinical Use Nuclear Receptors as Targets inCardiovascular Diseases NURR77 Family of Nuclear Receptors and its ModulatorsInduction of Drug Metabolism: The Role of Nuclear Receptors Nuclear Receptor Targeted Screening Libraries and Chemogenomics Approaches
- ISBN: 978-3-527-31872-8
- Editorial: Verlag Chemie
- Encuadernacion: Cartoné
- Páginas: 498
- Fecha Publicación: 23/07/2008
- Nº Volúmenes: 1
- Idioma: Inglés