Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology. The book is organized in four parts covering the foundational concepts of lipid biology all the way to the therapeutic opportunities they present. The first part is dedicated to the basic concepts of cellular lipid, the roles it plays in the cell, structure and physiology, regulation mechanisms, storage, and utilization. The second part is focused on lipid metabolism, covering the organelles involved lipid trafficking, metabolism in aging, cholesterol homeostasis, lipid droplets (LDs), and lipid oxidation. Part three is dedicated to the roles lipids play in specific disease states including renal, metabolic, cardiovascular, and fatty liver diseases. Other conditions include cancer, neurodegenerative diseases, and the intricate relationship between cellular lipids and autophagy. The final part covers therapeutic opportunities, including drug carrier systems, modeling lipid metabolism, and prevention therapeutics. Cellular Lipid in Health and Disease is a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry, and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities. Offers a complete and systematic coverage of lipid biology Provides foundational content and establishes the needed connections to translational aspects of the research in this area Includes chapters on the therapeutic opportunities presented by lipids INDICE: I introduction to Cellular Lipid 1. Roles of lipid in the cell 2. Structural and Physiological roles 3. (bio)Physical properties of lipid bilayers 4. Lipid regulation mechanisms 5. Intracellular lipid storage and utilization II Cellular Lipid Metabolism 6. Overview of organelles involved 7. Enzymes involved in lipid synthesis and remodelling 8. Cellular Lipid Trafficking 9. Lipid Metabolism in Aging 10. Cholesterol Homeostasis 11. Lipid droplets 12. Lipid Oxidation III Cellular lipid roles in diseases 13. Renal Disease 14. Lipodystrophy 15. Obesity and Diabetes 16. Cardiovascular Disease 17. Fatty liver disease 18. Cancer 19. Neurodegenerative Diseases 20. Immune diseases 21. Autophagy 22. Lipids and Viruses IV Therapeutic opportunities 23. Lipids as drug carrier systems 24. Drugs modeling lipid metabolism 25. Translational and preventive
- ISBN: 978-0-323-95582-9
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 450
- Fecha Publicación: 01/06/2023
- Nº Volúmenes: 1
- Idioma: Inglés