Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches concisely yet thoroughly examines the current principles of risk assessment in the area of human metal exposures with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations and computer models. Derived from the highly respected two-volume Handbook on the Toxicology of Metals, 4th edition (2014), the book summarizes the principles and methods providing examples of how MOA -TKTD can be used and how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics such as risk assessment, characterization, management and communication - the classic risk assessment paradigm - with mode of action, TKTD, and epidemiology, all related to human exposure. Written by pioneers in the field, Risk Assessment for Human Metal Exposures is an essential reference for researchers, students, and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health in one concise volumeProvides an easy to use structure to locate specific methods quicklyUses case studies to illustrate the methods and theories describedWritten to be understood by students, researchers, and industry workers needing to conduct risk assessment in metals and human health INDICE: 1. Introduction2. Exposure and Internal Dose3. Mode of Action (MOA) and Target Dose4. Hazard Identification5. Dose-Effect and Dose-Response Assessment6. Dose-Response for Essential Metals and the Evaluation of Mixed Exposures7. Applied Risk assessment8. Examples of current Risk Assessments of Human Metal Exposures and the need for MOA TKTD

• ISBN: 978-0-12-804227-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 320
• Fecha Publicación: 01/01/2018
• Nº Volúmenes: 1
• Idioma: Inglés