Mechanobiology: From Molecular Sensing to Disease provides a review of the current state of understanding of mechanobiology and its role in health and disease. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuliProvides a review of diseases with known or purported mechanobiological underpinningsIncludes the role of mechanobiology in tissue engineering and regenerative medicineCovers experimental methods to capture mechanobiological phenomena INDICE: Section 1: Mechanobiological basis of diseases 1.1 Osteoporosis 1.2 Cardiovascular mechanics and disease 1.3 Glaucoma and eye diseases 1.4 Growth and development 1.5 Tissue engineering and regenerative medicine Section 2: Cellular basis of Mechanobiology 2.1 Cells as strain gages and load cells 2.2 Cell - extracellular matrix interactions 2.3 Mechanobiological pathways 2.4 Mechanically mediated epigenetics Section 3: Experimental methods 3.1 Effects of shear stress on cells 3.2 Three-dimensional culture systems 3.3 Bioreactors 3.4 Tissue and organ on a chip systems Section 4: Computational simulations in mechanobiology 4.1 Cell aggregation 4.2 Growth models 5. Future prospects and challenges 6. Bibliography 7. Glossary
- ISBN: 978-0-12-817931-4
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 370
- Fecha Publicación: 01/10/2019
- Nº Volúmenes: 1
- Idioma: Inglés