Concepts and Methodology in Cancer Diagnostics: An Immunological, Biochemical and Molecular Approach

Concepts and Methodology in Cancer Diagnostics: An Immunological, Biochemical and Molecular Approach provides an exclusive combination of all basics and recent techniques, methodology, and advancements in the field of cancer diagnostics. With a strong focus on the procedures and techniques involved in cancer diagnostics, content also gives insights into the molecular tests required for different tumors for the administration of targeted drugs and precision medicine. In 11 chapters. The book also introduces the methods and technologies based on DNA and RNA based biomarkers, biochemical and immunological markers, genetic signatures, epigenetic changes and exosomes in blood, and tissue and body fluids. Readers will find a compilation of imperative topics and lists of the necessary materials and reagents needed, step-by-step instructions, readily reproducible laboratory protocols, as well as tips on troubleshooting and known pitfalls. This book is a valuable resource for medical professionals and researchers who want to understand the concepts of validated protocols and methodologies in diagnosing cancer, its prognosis, and predictive value. Discusses and provides solutions for quality control procedures in antibody tests in cancer diagnosticsGives insights into the limitations and biasness of biomarker testing, specifically immunohistochemical and molecular markersProvides procedures and addresses the challenges related to quality control, proficiency testing, accuracy, and precision of biomarker testing in cancerExplores numerous methods used in basic and diagnostic laboratories to characterize cancer-related biomarkers, including cancer risk assessment, diagnosis, and determination of cancer progression INDICE: 1. Introduction to tumor diagnostic and prognostic: Differences between conventional and current approaches2. Blood and other body fluid-based biomarkers in tumor cells- Methods and Protocol; A Biochemical and Molecular approaches3: Immunological markers in different cancers; Laboratory testing protocol and pitfalls4. Cancer biomarkers based on liquid biopsies; An update and challenges5. Oral salivary markers in different cancers: Current scenario in techniques and methodology.6. Common childhood cancers: Diagnostic and prognosis markers7. Oncometabolites in tumor cells: Current technique and procedure8. Immunohistochemistry based biomarkers in diagnosis of different types of tumor cells: techniques, procedures and troubleshooting9. Currently available immunohistochemical marker for tumor prognosis and therapeutics10. Molecular markers based on targeted therapy in different tumors11. Circulating tumor cell biomarkers, exosomal markers: Advances and laboratory approaches

• ISBN: 978-0-443-23593-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 200
• Fecha Publicación: 01/12/2024
• Nº Volúmenes: 1
• Idioma: Inglés