Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury.Provides in vivo and in vitro models to study human liver pathology.Explains the beneficial effects of antioxidants on liver diseases.Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation. INDICE: Foreward Section I: INTRODUCTION 1. The Liver: General Aspects and Epidemiology 2. Structure and Ultrastructure of the Normal and Diseased Liver Section II: LIVER PATHOPHYSIOLOGY 3. Hepatic Apoptosis and Necrosis: Mechanisms and Clinical Relevance 4. Autoimmune Hepatitis 5. Pathogenesis of Idiosyncratic Drug Induced Liver Injury 6. Acetaminophen 7. Liver Regeneration 8. Nitric Oxide in Ischemia-Reperfusion Injury 9. The Immune SYstem and Viral Hepatitis 10. Pathophysiology of Alcoholic Liver Disears (ALD) 11. Cytokines in Steatohepatitis 12. Redox Signaling in NASH 13. Pathophysiology of Hepatic Amoebiasis 14. Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica 15. Epigenetics in Liver Diseases: Involvement of Oxidative Stress 16. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis 17. Oxidative and Nitrosative Stress in Chronic Cholestasis 18. Cholestasis, Contraceptives and Free Radicals 19. Is Human Cirrhosis a Reversible Disease? 20. Obesity and Hepatocellular Carcinoma 21. Oxidative Stress as a Mechanism for HCC 22. NF-?B Actions During the Development of Hepatocellular Carcinoma 23. The Role of Senescence in HCC 24. Exercise, Liver Steatosis, and Free Radicals 25. Metabolic Syndrome, Oxidative Stress, and the Liver 26. Autophagy and Lipophagy in Liver Disease 27. Liver Diseases in the Elderly 28. Cytokines in Hepatic Injury 29. Nrf2: A Key Regulator of Redox Signaling in Liver Diseases 30. Redox Regulation by cMet/HGF in Liver Diseases. Section III. LIVER METABOLISM 31. Hepatic Metabolism in Liver Health and Disease. 32. Cytochrome P450 and Oxidative Stress in the Liver 33. Hepatic Drug Metabolism in Spinal Cord Injury Section IV. CIRRHOSIS AND ITS COMPLICATIONS 34. Complications of Cirrhosis: Introduction 35. Portal Hypertension. Molecular Mechanisms 36. Gastroesophageal Varices 37. Ascites 38. Free Oxygen and Nitric Radicals in Encephalopathy 39. Hepatorenal Syndrome 40. Hepatopulmonary Syndrome Section V. METHODS IN LIVER DISEASE 41. Experimental Models of Liver Damage Mediated by Oxidative Stress 42. Monitoring Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis 43. In Vitro Models of HCC Section VI. THERAPIES IN LIVER DISEASE 44. The Liver, Oxidative Stress and Antioxidants 45. Herbal Drugs on the Liver 46. Silymarin for Liver Disease 47. Naringenin and the Liver 48. Antioxidant, Anti- inflammatory, and Anti-fibrotic Properties of Quercetin in the Liver 49. Coffee and the Liver 50. Hepatoprotective Properties of Curcumin 51. Retinoids in Liver Function 52. Stevia as a Putative Hepatoprotector 53. Are N-Acetylcysteine and Resveratrol Effective Treatments for Liver Disease? 54. Does Nutrition Matters in Liver Disease? 55. One-Carbon Metabolism in Liver Health and Disease 56. Ursodeoxycholic Acid for the Treatment of Liver Disease 57. Current Treatment of HCV 58. An Adenosine Derivative Compound as a Hepatoprotective Agent 59. Nitric Oxide and the Liver 60. Repopulation of Cirrhotic Liver by Hepatic Stem Cells 61. Gene Therapy for Liver Disease 62. Role of Oxidative Stress in Liver Transplantation
- ISBN: 978-0-12-804274-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 992
- Fecha Publicación: 01/02/2017
- Nº Volúmenes: 1
- Idioma: Inglés