Neural degeneration and repair: gene expression profiling, proteomics and systems biology

With contributions from leading scientists around the world, including the USA, China and Japan, this is the first book focussing on the application of genomics, transcriptomics, proteomics, glycomics and systems biology in studying neural repair and degradation. INDICE: 1. INTRODUCTION Microarrays in Translational Neuroscience - from Laboratory to Clinical Applications 2. REACTIONS OF PERIPHERAL NERVE TO TRAUMATIC INJURY AND AXON REGENERATION The Potential of Genomewide Expression Profiling in Models of Peripheral Nervous System Injury and Repair Largescale Screening for Regeneration-Associated Neural Proteins and Genes Patterns of Genetic Regulation and Target Remodelling in Response to Molecular Signals to Neurons Microarray Analysis to Decipher Peripheral Nerve Myelination Unravelling the Mechanism of Neuropathic Pain using cDNA Arrays Comparison of Axotomy-induced Neuronal Gene Expression Profiles in Regenerating Peripheral Nerve and Non-regenerating CNS Fiber Tract 3. CENTRAL NERVOUS SYSTEM TRAUMA AND NEURODEGENERATIONSingle Cell Gene Expression and cDNA Microarray Analysis to Study Molecular Events in TBI, Neurological Degeneration and Restoration Gene Expression Changes Induced by Blocking or Ablation of Nogo A in Spinal Cord Injury and Brain Microarray Hybridization to Search for Genes Involved in Inhibition and Promotion of Spinal Cord Regeneration Proteomics Technology Applied to Traumatic BrainInjury: Implications for the Identification of Diagnostic Predictors and New Therapeutic Targets Molecular Changes in Neurodegenerative Disorders and Oxidative Stress Responses in Brain Injury Proteomics in Molecular Medicine: Applications to CNS Diseases 4. GLYCOMIC TECHNOLOGIES APPLIED TO NERVOUS SYSTEM FUNCTION Glycomic Approaches to Analyze Neural Functions of Glacosaminoglycans andProteoglycans Glycoproteomics and Glycan Profiling: Implications for Nervous System Function and Repair

• ISBN: 978-3-527-31707-3
• Editorial: Verlag Chemie
• Encuadernacion: Cartoné
• Páginas: 250
• Fecha Publicación: 13/02/2008
• Nº Volúmenes: 1
• Idioma: Inglés