Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips INDICE: 1. Techniques and Materials for the Fabrication of Microfluidic Chips2. Critical Factors Affecting Cells Behaviour in Microfluidic Chips3. Cell-Based Assays on Microfluidic Chips4. Cell Culture Techniques in Microfluidic Chips5. Skin-On-A-Chip6. Blood Vessels-On-A-Chip7. Heart-On-A-Chip8. Liver-On-A-Chip9. Lung-On-A-Chip10. Gut-On-A-Chip11. Kidney-On-A-Chip12. Immune Organs-On-Chip13. Nervous Systems on a Chip14. Eye-On-A-Chip15. Endocrine Organs-On-A-Chip16. Musculoskeletal Tissue-On-a-Chip17. Tumour-On-A-Chip18. Multi Organs-On-A-Chip and Personalized Medicine19. Computational modelling of organ-on-a-chip devices20. Commercialized Microfabricated Cell Chips21. Organs-On-A-Chip: Future perspectives
- ISBN: 978-0-12-823536-2
- Editorial: Woodhead Publishing
- Encuadernacion: Rústica
- Páginas: 350
- Fecha Publicación: 01/10/2022
- Nº Volúmenes: 1
- Idioma: Inglés