Beadchip molecular immunohematology: toward routine donor and patient antigen profiling by DNA analysis

This text is a review of molecular immunohematology (MI). It draws from analyses and case studies around the world and details many techniques used in manylabs. It is aimed at anyone interested in how MI is changing blood bank and transfusion medicine. 1. First book on the market to be used for courses such as: Specialist in Blood Banking ('SBB') and other accreditation programs in molecular immunohematology for Hospital and Blood Bank Transfusion Services, Transfusion Medicine, and reference laboratories 2. Offers thorough review of molecular immunohematology, particularly the BeadChip technology developed by BioArray Solutions 3. Draws from analyses and case studies around the world, detailing techniques used in many labs INDICE: An overview of the Classical Serological methods: limitations and benefits of serology and DNA testing.- Introduction to Molecular Typing.- The BeadChip System: A Flexible Array Format for Complex Nucleic Acid and Protein Analysis.- Implementation of HEA at Blood Centers: Prescreening, Rare Donors, Inventory Management.- Implementation of HEA BeadChip System at Medical Centers: Providing Extended Matched Units and Eliminating Complex Workups for Patients.- Human Platelet Antigen Genotyping and Diagnosis of Antiplatelet Alloimmunization.- Blood group genotyping by high-throughput DNA-analysis: Application to the Panel National de Référence du CNRGS.- Implementation and Assessment ofHigh-Throughput Donor Typing at the Milan, Italy Immunohematology Reference Laboratory.- Implementation of the BioArray Erythrocyte Antigen (HEA) genotyping System BeadChip™ HEA: The Red Cross of Spain Experience.- Looking Beyond HEA: Matching SCD Patients for RH Variants Marion E Reid*, Christine Halter Hipsky.- Identification of Altered RHD and RHCE Alleles: A Comparison of Manual andAutomated Molecular Methods.- Bayesian Classification Algorithms for Automated Allele Assignment.

• ISBN: 978-1-4419-7511-9
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 29/11/2010
• Nº Volúmenes: 1
• Idioma: Inglés