The Golgi Apparatus: The First 100 Years traces the first century of GA discovery from the first published accounts in 1898, to the Centenary Celebration in 1998, to our most recent discoveries. It summarizes the past 50 years beginning with the modern era of GA discovery in 1954, leading up to the present erawith almost exclusive focus on molecular biology. Emphasized are organizationand function (especially in plants), the existence and importance of cisternal tubules, development of methods of plant and animal GA isolation and subfractionation, the concept of GA function as part of an integrated system of internal endomembranes, evidence for differentiation of membranes across the stacksof GA cisternae, and flux of membrane constituents along the polarity gradient defined by membrane differentiation all culminating in the membrane maturation or flow differentiation model of GA function. More recent contributions to GA in cell growth (enlargement) and to cancer are summarized in the final chapters. Presents a historical review of Golgi Apparatus research. Offers a summarization of the the modern era of Golgi Apparatus discovery including cell fractionation and biochemical analysis. Focuses on molecular biology and discusses cell growth contributions. INDICE: History of the Golgi Apparatus.- Morphology of the Golgi Apparatus(Architecture/Structure).- Isolation and Subfractionation.- Golgi Apparatus Tubules.- Golgi Apparatus and Membrane Biogenesis.- Golgi Apparatus Function inthe Flow-Differentiation of Membranes.- Biochemistry of the Golgi Apparatus.-Golgi Apparatus Function in Secretion.- Golgi Apparatus Replication.- Cell Free Systems for Study of Golgi Apparatus Function.- Golgi Apparatus Function inGrowth and Cell Enlargement.- The Golgi Apparatus and Cancer.- The Golgi Apparatus: A Look Ahead.
- ISBN: 978-0-387-74346-2
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 570
- Fecha Publicación: 01/01/2008
- Nº Volúmenes: 1
- Idioma: Inglés