Gaba and sleep: molecular, functional and clinical aspects

GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep.The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events. Focuses on the neuropsychopharmacology of GABA and its role in sleep and wakefulness Presents neurochemical, electrophysiological, and neuropharmacological approaches to understand GABAergic mechanisms Offers an overview of current approaches and medications Features contributing authors who are leading experts in the field of sleep and neuropharmacology INDICE: Part I Basic Physiology and Pharmacology.- Physiology and Pharmacology of the GABA System: Focus on GABAA and GABAB Receptors.- Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy.- Distribution of GABAA Receptor Subunits in the Human Brain .- Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics.- Part II Sleep Science and Circuitry.- Sleep and Its Modulation by Substances That Affect GABAA Receptor Function.- Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the ReticularActivating System.- Function of GABAB and GABAC Receptors in the Regulation of Basic and Higher Integrated Sleep-Waking Processes.- Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness.-GABA-ergic Modulation of Pontine Cholinergic andNoradrenergic Neurons for Rapid Eye Movement Sleep Generation.- Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT–PPT) in the Promotion of REM Sleep.-GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site – in the Modulation of Sleep–Wake States.- The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep.- Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms.- GABA Involvement in the Circadian Regulation of Sleep.- Part III Neurotherapeutics Pathophysiology of Sleep Disorders.- Insomnia: Differential Diagnosis and Current Treatment Approach.- Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients.- Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia .- Indiplon Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia.

• ISBN: 978-3-0346-0225-9
• Editorial: Birkhaüser
• Encuadernacion: Cartoné
• Páginas: 470
• Fecha Publicación: 05/10/2010
• Nº Volúmenes: 1
• Idioma: Inglés