The impact of tumor biology on cancer treatment and multidisciplinary strategies

This book provides a detailed overview of the fundamentals of tumor biology and the influence of biologic factors on the design of therapeutic strategies and the outcome of established and emerging treatments. Particular attention isdevoted to multidisciplinary combined modality therapy. The topics reviewed include tumorigenesis, cell proliferation, angiogenesis, physiology of malignant tissues, adhesion and invasion, development of metastases, and the role of the immune system. Subsequent chapters discuss the principles of chemotherapy, radiotherapy, and molecularly targeted therapy, explain treatment resistance, and provide strategies for rational combinations, including the design of translational studies. Furthermore, the principles and clinical implications of diverse new diagnostic and therapeutic approaches are presented. The chapters inthis book have been written by an outstanding group of basic scientists, clinical researchers, and cancer professionals with long experience in the field Provides a detailed overview of the fundamentals of tumor biology and the influence of various biologic factors on the design of therapeutic strategies and the outcome of established and emerging treatments Particular attention is devoted to multidisciplinary combined modality therapy All of the chapters have been written by experienced basic scientists, clinical researchers, and cancer professionals INDICE: From the contents Tumorigenesis.- Tumor Growth/Cell Proliferation.- Angiogenesis.- Tumor Physiology.- Adhesion, Invasion, Integrins and Beyond.-Development of Metastases.- Role of the Immune System in Cancer Development/Therap. Implications.- Cancer Prevention .- Tumor Detection by Morphological and Biological Imaging.- Tumor Detection by Biological Markers.- Quantitative Cell Kill by Chemo-/Radiotherapy.- Impact of Molecularly Targeted Agents on CellKill in Bi- or Trimodal Approaches.- Translational Studies for Target-Based Drugs.- Molecular and Physiological Mechanisms of Treatment Resistance.- Influence of Repopulation on Treatment Resistance.- Molecular Tools, Gene ExpressionProfiling.- Strategies of Gene Transfer/Silencing and Technical Considerations.- Tumor Biology’s Impact on Clinical Cure Rates.- Can Dose-Escalated Radiotherapy Eventually Cure All Biologically Distinct Subsets of a Certain Tumor Type?

• ISBN: 978-3-540-74385-9
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 350
• Fecha Publicación: 01/12/2008
• Nº Volúmenes: 1
• Idioma: Inglés