Oxidative stress in aging: from model systems to human diseases

Oxidative Stress in Aging: From Model Systems to Human Diseases discusses therole of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions inhumans (following an introduction section of the basics and theory of free radicals). Human aging is a complex phenomenon - not everyone gets the same diseases and dies from the same cause. Accumulating reports implicate the connection between free radicals and various diseases and age-related pathological conditions. Although the causal relationships have not been established, it is necessary to discuss how free radicals are involved in each situation. In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed. State-of-the-art overview of the free radical theory of aging and oxidative biochemistry. Evaluates the role of oxidative stress in the aging process in different model organisms. Discusses connection between free radicals, various diseases, and age-related pathological conditions. Reviews major interventions trials of antioxidant supplements in age-related diseases INDICE: Introduction to the Free Radical Theory of Aging. Reactive Oxygen Species, Antioxidant Defence and Repair/Removal of Damage. (Technical Considerations for Experiments). Fibroblast. Podospora. Yeast. C. Elegans. Drosophila.Mice. Rhesus Monkeys. Comparative Biology of Vertebrate Lifespans. Diabetes. Alzheimer's Disease, Parkinson's Disease. Atherosclerosis. Ischemia Reperfusion. Effect of Antioxidant Enzyme Manipulation on Ischemia, reperfusion in Mice.Immune Dysfunction. Cancer. Epidemiological review of the major pharmacological interventions trials. Possible Reasons why Antioxidant Supplements Do not Work.

• ISBN: 978-1-58829-991-8
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 390
• Fecha Publicación: 01/05/2008
• Nº Volúmenes: 1
• Idioma: Inglés