The Institute of Medicine has declared the understanding of this topic an essential public health competency. This resource provides a comprehensive overview of the emerging and essential topic of genomics and genetics in public health. It examines the basic molecular genetics; principles of genetic epidemiology; ethical, legal, and social implications of genetics; and clinical applications to disease prevention throughout the life cycle. The book covers such keytopics as History and Philosophy of Public Health Genetics; Genomics and Government; The Basic Science of Genetics; Polymorphisms and Gene-Environment Interactions; and much more. INDICE: List of Tables, Figures, and Exhibits. Foreword. Preface. The Authors. Introduction. Part One: Scientific and Social Perspectives on Genomics. One: Past, Present, and Future of Public Health Genomics. History of Human Genetics. History of Public Health Genetics. Impact of Genetics on Primary, Secondary, and Tertiary Prevention. Phenotypic versus Genotypic Prevention. GenomicsToday. Genomics Tomorrow. Two: Genomics and Government. The NIH and the NHGRI. The NOPHG. The SACGHS. State Government Programs. Genomics and Bioterrorism Preparedness. Three: Basic Molecular Genetics. Hereditary Material. DNA Replication. Transcription and Translation. Gene Expression. Mutations and Polymorphisms. Four: Mutations, Population Genetics, and Ethnicity. Somatic versus Germline Mutations. Types of Mutations. Causes of Mutations. Population Genetics. Race, Ethnicity, and Genomics. Five: Inheritance Patterns and Family History. Gregor Mendel and His Pea Plants. Autosomes and Sex Chromosomes. Drawing a Pedigree. Non-Mendelian Inheritance Patterns. Inheritance Patterns, Family History, and Public Health. Six: Genetic Epidemiology and Gene-Environment Interactions. Review of Basic Concepts. Polygenic and Multifactorial Traits. Determining the Risk of Multifactorial Disorders. Determining Genetic versus Environmental Effects. Determining Patterns of Inheritance and Localizing Genes. Gene-Environment Interactions and Molecular Epidemiology. Seven: Genetic Information, Ethics, and the Law. Examples of Genetic Discrimination and Breach of Privacy.Evolution of Privacy and Antidiscrimination Laws. Genetics Research and Concern for Privacy. Clinical Genetic Testing and the Duty to Inform. Part Two: Genomics in Maternal, Child, and Adult Health. Eight: Toxicology, Teratology, andPrenatal Diagnosis. Birth Defects and Embryology. Chromosomes. Prenatal Diagnosis. Preimplantation Genetic Diagnosis. Nine: Preconceptional Genetic Screening and Cultural Competence. Genetic Diseases Common among People of AshkenazicJewish Descent. Genetic Diseases Common among People of Sephardic and MizrahiJewish Descent. Reproductive Options for Carriers. Limitations of Ethnically Based Genetic Screening. Ten: Metabolic Disorders and Newborn Screening. Newborn Screening's Relevance to Public Health. Biology of Metabolic Disorders. Newborn Screening in California. MS/MS-Detectable Disorders. Eleven: Pediatric Genetics and Health Supervision. American Academy of Pediatrics. Achondroplasia.Down Syndrome. Fragile X Syndrome. Marfan Syndrome. Prader-Willi Syndrome. Autism. Twelve: Adult Genetics, Genetic Counseling, and Health Behavior. Alzheimer's Disease. Cardiovascular Disease. Cancer. Familial Cancer Syndromes. Genetic Testing, Risk Perception, and Health Behavior. Part Three: Areas of GeneralInterest. Thirteen: Health Economics, Health Disparities, and Genetic Services. Basics of Health Economics. Health Economics of Genetic Screening. Health Care Disparities in Genetic Screening. Fourteen: Genomics and Communicable Disease Control. Bacteria. Viruses. Genomics of a Pandemic. Fifteen: Hot Topics inGenomics. Personalized Medicine. Gene Therapy. Stem Cell Research. Sixteen: Bioinformatics and Genomics Online. Clinical and Community Resources. Ethical, Legal, and Social Issues. Genetic Epidemiology. Government Agencies. Maternal and Child Health. Professional Genetics Education. Professional Genetics Societies. Professional Public Health Societies. Research Resources. Appendix 1: Answers to Selected Discussion Questions. Glossary. References. Index.
- ISBN: 978-0-7879-8684-1
- Editorial: Jossey Bass
- Encuadernacion: Rústica
- Páginas: 304
- Fecha Publicación: 12/11/2008
- Nº Volúmenes: 1
- Idioma: Inglés