Experts from all areas of academic and medical research in hematology, oncology, cardiology, and pathology, take readers from the bench research through the role of platelets in disease, to new therapeutic approaches. Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 125 world experts from 14 countries. This award-winning reference provides clear presentations by basic scientists of the cellular, molecular, and genetic mechanisms of platelets and the subsequent pathophysiological processes such as thrombosis, hemorrhage, inflammation, and cancer. It also provides clear presentations by hematologists, oncologists, cardiologists, pathologists, and other clinicians on how antiplatelet therapy, gene therapy, and platelet transfusion can lead to new therapeutic approaches to diagnose and treat thrombosis and other cardiovascular diseases. Since the publication of the third edition, there continues to be a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. This Fourth Edition of Platelets will continue to draw all this information into a single, comprehensive and authoritative resource. Presents a comprehensive, translational source for all aspects of platelet biology, pathophysiology, and clinical manifestations in one reference workContains new chapters on topics such as the regulators of GPVI signaling, in vivo thrombosis evaluations, pharmaco genomics of platelets, interplay between anti-platelets and anti-coagulants in clinical practice, and redox regulation of platelet functionSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of plateletsProvides a full color reference with 250 illustrations and over 12,000 references INDICE: Part One Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. Platelet Structure 4. The Platelet Cytoskeleton 5. Platelet Genomics and Proteomics 6. Platelet Receptors 7. The Glycoprotein Ib-IX-V 8. Integrin aIIbb3 9. Thrombin Receptors 10. The Platelet P2 Receptors 11. PECAM-1 12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium 13. Inhibition of Platelet Function by the Endothelium 14. Platelet Polymorphisms 15. Platelet Secretion 16. Signal Transduction during Platelet Plug Formation 17. Outside-In Signaling by Integrin aIIbb3 18. Platelet Thrombus Formation in Flowing Blood 19. Interactions between Platelets and the Coagulation System 20. Platelet-Derived Microparticles 21. The Role of Platelets in Fibrinolysis 22. Platelet Function in the Newborn Part Two Tests of Platelet Function 23. Clinical Tests of Platelet Function 24. Platelet Counting 25. The Bleeding Time 26. Platelet Aggregation 27. The VerifyNow System 28. The Platelet Function Analyzer (PFA)-100 29. Impact Cone and Plate(let) Analyzer 30. Flow Cytometry 31. Thromboxane Generation 32. Perfusion Chambers 33. Animal Models 34. Real-Time in Vivo Imaging of Platelets during Thrombus Formation Part Three The Role of Platelets in Disease 35. Atherothrombosis and Coronary Artery Disease 36. Central Nervous System Ischemia 37. Peripheral Vascular Disease 38. Diabetes Mellitus 39. Inflammation 40. Antimicrobial Host Defense 41. Angiogenesis 42. Tumor Growth and Metastasis 43. Alzheimer's Disease 44. Psychiatric Disorders Part Four Disorders of Platelet Number and Function 45. The Clinical Approach to Disorders of Platelet Number and Function 46. Immune Thrombocytopenic Purpura 47. HIV-1-Related Thrombocytopenia 48. Heparin-Induced Thrombocytopenia 49. Drug-Induced Thrombocytopenia 50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome 51. Thrombocytopenia in Pregnancy and the Newborn 52. Alloimmune Thrombocytopenia 53. Inherited Thrombocytopenias 54. Pseudothrombocytopenia 55. Thrombocytosis and Essential Thrombocythemia 56. Inherited Disorders of Platelet Function 57. Acquired Disorders of Platelet Function 58. Cardiopulmonary Bypass Part Five Pharmacology: Antiplatelet Therapy 59. Aspirin 60. ADP Receptor Antagonists 61. aIIbb3 (GPIIb-IIIa) Antagonists 62. Dipyridamole 63. Cilostazol 64. Experimental Antiplatelet Therapy Part Six Pharmacology: Therapy to Increase Platelet Numbers and/or Function 65. Platelet Growth Factors 66. Desmopressin (DDAVP) 67. Factor VIIa Part Seven Platelet Transfusion Medicine 68. Platelet Storage and Transfusion 69. Platelet Substitutes and Novel Methods of Platelet Preservation Part Eight Gene Therapy for Platelet Disorders 70. Gene Therapy for Platelet Disorders
- ISBN: 978-0-12-813456-6
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 1400
- Fecha Publicación: 01/03/2019
- Nº Volúmenes: 1
- Idioma: Inglés