Synaptic transmission is the process by which neurons communicate with one another at synapses, which is essential for normal function of the central and peripheral nervous systems. Synaptic dysfunction is linked to a number of conditions affecting the nervous system, including schizophrenia, Alzheimer's disease, Parkinson's disease, impairments in muscle control, and other neurological disorders. Synaptic Transmission is a comprehensive guide to the topic of neurotransmission, providing an in-depth discussion of many aspects of synapse structure and function, a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on the topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders, training future researchers and clinicians in this critical discipline. A comprehensive reference on synaptic structure, physiology, function, and neurotransmissionDiscusses many landmark experiments in the field of synaptic transmission to emphasize core principlesChapters include references to primary scientific literature, relevant review articles, and books, many of which could be assigned as discussion material for courses focused on this topic INDICE: 1. Introduction Part 1: Synaptic Biophysics and Nerve Terminal Structure 2. The formation and Structure of Synapses 3. Basics of Cellular Neurophysiology 4. Ion Channels and Their Role in Generating Action Potentials 5. Electrical Synapses Part 2: Regulation of Chemical Transmitter Release 6. Function of Chemical Synapses and the Quantal Theory of Transmitter Release 7. Calcium Homeostasis, Calcium Channels, and Transmitter Release 8. Cellular and Molecular Mechanisms of Exocytosis 9. Cellular and Molecular Mechanisms of Endocytosis and Synaptic Vesicle Trafficking Part 3: Receptors and Signaling 10. Introduction to Receptors 11. Ionotropic Receptors 12. Metabotropic G-protein-coupled Receptors and Their Cytoplasmic Signaling Pathways 13. Synaptic Integration Within Postsynaptic Neurons 14. Synaptic Plasticity Part 4: Chemical Transmitters 15. Introduction to Chemical Transmitter Systems 16. Acetylcholine 17. Monoamine Transmitters 18. Amino Acid Neurotransmitters 19. Neuropeptide Transmitters 20. Gaseous Neurotransmitters 21. The Use of Multiple Neurotransmitters at Synapses 22. Complex Signaling Within Tripartite Synapses
- ISBN: 978-0-12-815320-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 550
- Fecha Publicación: 01/06/2019
- Nº Volúmenes: 1
- Idioma: Inglés