Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling.This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans , microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesisis discussed as well as the use of model organisms in elucidating ECM function. First volume of this re-launched series -An excellent introduction to the biology of the extracellular matrix -Published in collaboration with the American Society for Matrix Biology INDICE: An overview of extracellular matrix structure and function. Fibronectin and other adhesive glycoproteins. Collagen: suprastructures and collagen fibril assembly.- Asement membrane; Hyaluronan and the Aggregating Proteoglycans. The small, leucine-rich proteoglycans. Microfibrils and fibrillin. Elastin. Lysyl oxidase and lysyl oxidase-like enzymes. The Fibulins. Matricellular proteins.
- ISBN: 978-3-642-16554-2
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 425
- Fecha Publicación: 01/02/2011
- Nº Volúmenes: 1
- Idioma: Inglés