Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ SystemsMolecular Pathology/Basic Mechanisms of DiseasesAnimal Models/Other Model SystemsExperimental PathologyClinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targetingArticles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of Normal and Disease anatomy and histology images Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions INDICE: Adaptive Immune SystemSpecialization in adaptive immunityRegulation and maintenance of adaptive immunityAllergy and hypersensitivityThe Pathobiologic Basis of AutoimmunityDefining Traumatic InjuriesAtrophy, hypertrophy and hyperplasiaAutophagyUbiquitin-proteasome systemMechanisms of cell injuryLysosomesPeroxisomesEndoplasmic reticulum: ER stressMitochondrial calcium homeostasis in cell health and diseaseInner Membrane Permeabilization - The Permeability TransitionExtrinsic pathways: death receptors and granzymesCaspases: executioners of apoptosisNecrosisBiological ToxinsRegulation of Mitochondrial Apoptosis: Bcl-2 and its Family MembersLaterality DisordersTrisomiesChromosome 22q AbnormalitiesSex Chromosome AbnormalitiesTriplet Repeat DisordersImprinting DisordersMitochondrial Myopathies Inborn Errors of MetabolismEhler-DanlosMuscular DystrophiesChannelopathiesOther congenital myopathiesCongenital InfectionPerinatal Complications of Maternal DiabetesSudden Infant Death SyndromeNeuroblastic TumorsInteractions of Pathogens with the Entire HostDiseases Caused by FungiPrinciples of Diagnosis of Infectious DiseasesAn Overview of InflammationThe complement systemMediators and mechanisms of the increased blood flow, vascular permeability and blood vessel proliferation in inflamed tissueCells of innate immunity: mechanisms of activationRecruitment of leukocytes: adhesion molecules and chemoattractantsPhagocytes in inflammationChronic inflammationSystemic InflammationSepsis: understanding the high mortality and high morbidityResolution and Regulation of InflammationAn introduction to the conspicuous and distinguishing characteristics of neoplasmsEpigenetic contributions to the cancer transcriptomeEstablishment of replicative immortality in cancer cellsMechanisms of resistance to cell death pathways in cancer cellsCancer angiogenesis and vasculogenesisThe cancer tissue microenvironmentCancer invasion and metastasisAvoidance of cancer cell destruction by the immune systemDeregulation of the cellular energetics of cancer cellsSystemic effects of cancerGenetic and Epigenetics of Type 2 DiabetesSkeletal muscle glucose metabolism and insulin resistanceNormal adipose tissue biology (adipokines and inflammation).Recent Advances in Genomics of Body Composition, Adipose Tissue Metabolism and its Relation to the Development of ObesityThe gut microbiota and effects on metabolism.Infant malnutrition.Cell cycle and metabolic changes during tissue regeneration and remodelingScar Formation & Skin Wound HealingSkin RegenerationSkeletal Muscle Remodeling and RegenerationMyocardial Remodeling and RegenerationRepair and Regeneration following Spinal Cord InjuryCell mediated rejectionAllograft toleranceXenotransplantationLiverLungPancreas and Islet Transplantation For The Treatment of Diabetes MellitusBone MarrowImmunosuppressionBiology of Normal BoneCell, Biochemistry, and Molecular Biology of BoneGenetic Nonneoplastic DiseasesSporadic Acquired and Genetic Disorders of BonePaget's DiseaseOsteomyelitisMetabolic Bone Diseases IMetabolic Bone Diseases IIFluorosisBenign Tumors and Tumor-like Conditions of BoneMalignant TumorsThe Pathology of the Skeleton in Lysosomal Storage DiseasesThe Normal Breast and Risk Factors for Breast CancerProliferative Lesions and Preneoplastic AlterationsInvasive CarcinomaTranslational Cellular Model Systems to Study Breast CancerBreast Cancer Metastasis: Clinical ConsiderationsIschemic Heart DiseaseHeart Valve DiseaseMyocarditis and other inflammatory myocardial disease (e.g., sarcoid)Cardiovasacular PathologyInfluenza in animalsZoonosesComparative Pancreatic PathologyInfectious Disease - PrionsSkin: Basic Structure and FunctionCutaneous ImmunologyMelanocytes and vitiligo (and hair graying)Disorders of Epidermal Maturation (ichthyosis)Inflammatory skin disordersBenign epithelial tumorsMalignant epithelial tumorsBenign melanocytic lesions and MelanomaBasic principlesThyroid - Inflammatory diseaseThyroid - mouse models of thyroid neoplasia, insight into thyroid pathophysiologyPathophysiology and Neoplasia of the Adrenal Medulla and Extra-Adrenal ParagangliaParathyroid: Pathophysiology and Molecular Mechanisms of DiseaseDevelopment, structure and function of the tubal gutStomachSmall bowelThe large bowelInflammatory bowel diseaseGastric cancerGastrointestinal Polyposis SyndromesColorectal cancerHeritable ovarian cancerOvarian carcinogenesisMolecular basis for targeted therapy in gynecologic cancerPolycystic Ovarian DiseaseViral associations with head and neck carcinoma: HPVSquamous dysplasia: pathogenesis and histologic gradingFungal infections in the head and neckNormal HematopoiesisNormal Karyotype Acute Myelogenous LeukemiaChronic Lymphocytic Leukemia - Molecular pathology and relevance to novel therapiesMolecular genetics of diffuse large B-cell lymphomaMantle Cell LymphomaHodgkin Lymphoma and the microenvironmentPlasma cell neoplasms: MGUS and MyelomaFollicular lymphoma: Early and late genetic eventsPathobiology of peripheral T-Cell lymphomasPathogenesis of pediatric acute lymphoblastic leukemiasCellular Anatomy of the Liver (Hepatocyte, Biliary Epithelial Cells (BEC), Hepatic Stellate Cells (HSC), Kupffer cells and Endothelial cells)Liver Physiology: Metabolism and DetoxificationLiver Development, Regeneration, and Stem CellsBioartificial LiverHepatic fibrosis and cirrhosisFatty liver, Non-alcoholic Steatohepatitis (NASH) and Alcoholic liver diseaseDrug-induced liver injuryViral HepatitisMonogenetic Liver DiseasesBiliary DiseaseExperimental HepatocarcinogenesisPhysiopathology of hepatocellular carcinomaCholangiocarcinomaBiology of Normal Joint and Evaluation of the Joint Including Clinical, Imaging and Pathologic EvaluationThe Pathobiology of OsteoarthritisCrystal DiseasesInflamatory-Juvenile Idiopathic ArthritisNodular FasciitisSuperficial fibromatosesDesmoid fibromatosisTargeting Oncogenic Pathways in Dermatofibrosarcoma Protuberans and Inflammatory Myofibroblastic TumorAdipocytes in normal tissue biologyParkinson's diseaseAmyotrophic lateral sclerosis and other Motor neuron diseasesHuman Prion DiseasesCorneal pathologiesLens: structure / function and pathologiesOuter retinal degenerations genetic and non-geneticOptic nerve structure and pathologiesHyaloid vasculature: structure and pathologiesRetinal vasculature: structure and pathologiesOuter retinal vasculature structure and choroidopathiesOcular tumorsThe eyelid: structure, function and pathologyNormal Pancreatic DevelopmentAnatomy, Histology and Function of the PancreasPancreatitisPancreatic Cancer and its Precursor LesionsAltered Signaling Pathways and Potential Therapeutic Targets in Pancreatic CancerCell of Origin and Mouse Models for Pancreatic CancerNeuroendocrine Tumors of the PancreasNormal structure and function of the placentaHuman Placental development from conception to termPlacental vasculogeneis/angiogenesisEmbryonic and fetal red blood cell developmentOverview of Human Implantation(B) The immunology of the placentaPlacental pathologies â?? intrauterine infectionsChronic Inflammatory Entities of the PlacentaPathologic Effects of Maternal Hypertension and Defective Placentation on Placental Growth and DevelopmentThe Placenta in Obesity and Diabetes MellitusPlacental Pathologies-MiscellaneousMammalian placentation and implications for animal modelsGestational trophoblastic diseaseNeuroendocrine Prostate CancerTesticular Anatomy and PhysiologyNon-Neoplastic Disorders of the TestesTesticular TumorsSemen Analysis, Male Infertility, and Male ContraceptionPsychobiology of AutismObsessive Compulsive DisorderUse of Functional Connectivity to Identify Brain Circuits Involved in PsychopathologyIntroductory anatomy, histology and cell biology of the lungCell death and repair in lung diseasePulmonary Development and Pediatric Lung DiseasesAsthmaEmphysemaPulmonary hypertension/ Pulmonary arterial hypertensionPulmonary fibrosisPathogenesis and Mechanisms of Asbestosis and SilicosisPathobiology of the Acute Respiratory Distress SyndromeThoracic Neoplasia-CarcinomaThoracic Neoplasia-MesotheliomaNormal urinary tract development and anomaliesNormal kidney functionGlomerular diseaseMesangiopathies: IgA NephropathyEndotheliopathiesImmune mediated glomerular injuryAntibody mediated glomerular injuryComplement mediatedMetabolic glomerular injuryMonoclonal gammopathies (glomerular & tubular injuries)Tubulointerstitial diseasesInfectious diseases - HIV, HEP B, C, BK and other virusesRenal tumors to include WilmsBladder tumorsInfectious Diseases - Urinary Tract Infections (bacterial) Normal Vascular Structure and FunctionModes of neovascularization in tumors and clinical translation of antiangiogenic therapyHypertensionAtherosclerosisVascular Aneurysms and DissectionsVasculitidesVascular TumorsUse of human biospecimens for researchRegulatory aspects of biospecimen collection and distributionBiorepository operations and infrastructureClinical annotation and data managementBiorepository Quality AssuranceBiorepository Management and Cost StructureThe RBC as a Physiological Object in the CirculationThe Red Blood Cell as a Target of DamageRed Blood Cell StorageThe Therapeutic Use of Red Blood CellsThe Platelet as a Multifunctional Cell in the CirculationThe Platelet as a Target of DamagePlatelet StoragePlasma Components as Targets of DamagePlasma Component StorageThe Therapeutic Use of Plasma Components and DerivativesComplications of TransfusionAssay DevelopmentAssay PrinciplesTest InterpretationMicrobiologyHematologyMolecular DiagnosticsIntroduction to CytogeneticsIntroduction to Basic Cytologic DiagnosisCervical Cytology (The Pap Test)Non-Gynecologic Fluid and Brushing CytologyFine Needle Aspiration CytologyEpigeneticsGene/Genome Mutation Scanning and TestingThe Human Genome Project and Personalized MedicineWhat is Postmortem Pathology: The Why and How We Do ItRecent Contributions of Post-mortem Pathology to the PublicToxicology in Post-mortem PathologyThe Negative AutopsyRadiology, Forensic Imaging and the virtual autopsyGenetics and the Molecular AutopsyGeneral Approaches in Surgical PathologySurgical Pathology of Inflammatory Conditions of the GI TractSurgical Pathology of Malignant NeoplasmsSurgical Pathology of CarcinomasSurgical Pathology of SarcomasSurgical Pathology of Melanocytic NeoplasmsSurgical Pathology of Neoplasms of the Central Nervous SystemSurgical Pathology of Hematopoietic NeoplasmsHistorical Roots of Flow CytometryHardware: The Flow CytometerFlow Cytometry SoftwareReagents/StainingDigital Imaging FundamentalsImage analysisApplications of Image Science to Diagnostic PathologyEnzyme HistochemistryHistory of ImmunohistochemistryFixation and Tissue ProcessingImmunohistochemistry: Antibody SpecificityAntigen Retrieval TechniquesIHC Detection MethodsDetection of Apoptosis and AutophagyOptical coherence tomographyConfocal endomicroscopyPhotoacoustic imagingDiffuse optical imagingMolecular imagingIntravital microscopyCT applications for radiation treatment of cancersMagnetic Resonance ImagingfMRICardiac imagingPETNucleic acid extractionIn vitro amplification techniquesIn situ techniquesQuality AssuranceCirculating Tumor CellsNext GenerationHow do Bioinformatics Approaches Apply to the Analysis and Understanding of Disease Pathology?Aplastic AnemiaParoxysmal nocturnal hemoglobinuriaDisorders of iron metabolism: iron deficiency and iron overload and anemia of chronic diseasesHeme biosynthesis and its disorders: porphyrias and sideroblastic anemiasMegaloblastic anemiasHemoglobinopathies and thalassemia syndromesHemolytic anemiasNormal coagulation and hemostasisPlatelet disordersCongenital coagulopathiesAcquired coagulopathiesDisorders of coagulation in the neonateThrombotic thrombocytopenic purpura and the hemolytic uremic syndromeAntithrombotic drugs and their complications
- ISBN: 978-0-12-386456-7
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 5000
- Fecha Publicación: 12/09/2014
- Nº Volúmenes: 1
- Idioma: Inglés