Epigenetic Toxicology: Core Principles and Applications

Epigenetic Toxicology: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration; however, its integration into the field of toxicology is in its infancy. Increasing the presence of epigenetics in toxicological research will allow for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Unified, practical, and easy to follow protocols are included to help improve effectiveness and efficiency both the classroom and the laboratory. Protocols are available online as PDFs to increase practical applicability and facilitate incorporation of epigenetics into toxicology research programs. Epigenetic Toxicology: Core Principles and Applications is an essential book for advanced students and researchers using epigenetics in toxicology research and study. Presents the fundamental principles of epigenetics for toxicologists with a broad range of backgroundsDiscusses the incorporation of epigenetics and epigenomics into current toxicological studiesIncludes basic protocols covering most epigenetic endpoints INDICE: 1. Introduction to the Epigenome2. Introduction to Chromatin3. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation4. The Role of Histone Methylation and Methytransferases in Gene Regulation5. Implications for Chromatin Biology in Toxicology6. Role of DNA Methylation in Gene Regulation7. Implications of DNA Methylation in Toxicology8. DNA Methylation as a biomarker in Environmental Epidemiology9. Role of Non-coding RNAs in Gene Regulation10. miRNAs as Biomarkers of Toxicant Exposure11. Chromatin Immunoprecipitation (ChIP): General Protocol and Considerations for Analysis of Chromatin Modifications and Transcription Factor Binding12. Methods for Analysis of DNA Methylation13. Methods for Analyzing miRNA Expression

• ISBN: 978-0-12-812433-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 250
• Fecha Publicación: 01/08/2018
• Nº Volúmenes: 1
• Idioma: Inglés