Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes. Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitusExplores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complicationsInvestigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition INDICE: Section 1: General and Introductory Aspects 1. Nutrition and diabetes: general aspects   Ana M. Wägner, Julia Charlotte Wiebe, Rosa M. Sánchez-Hernández and Lidia García-Pérez 2. Dietary patterns and insulin resistance   Marcio A. Torsoni, Adriana Souza Torsoni and Marciane Milanski 3. Beta cell metabolism, insulin production and secretion; metabolic failure resulting in diabetes   Younan Chen, Vinicius Fernandes Cruzat and Philip Newsholme 4. Diet-gene interactions in the development of diabetes   Jose M. Ordovas 5. Pathogenesis of type 1 diabetes: role of dietary factors   Julie Christine Antvorskov, Karsten Buschard and Knud Josefsen Section 2: Molecular biology of the cell 6. Oxidative stress in diabetes mellitus: molecular aspects: implications for the diet   Lu Cai 7. Mitochondrial function in insulin resistance and use of SiRNA for catalase inhibition   L. R. Silveira 8. Muscle protein in type 2 diabetes: Molecular aspects   Antonio Zorzano 9. Mechanisms whereby wholegrain cereals modulate the prevention of type-2 diabetes   Knud Erik Bach Knudsen, Kjeld Hermansen, Mette Skou Hedemann and Merete Lindberg Hartvigsen 10. Peroxisome proliferator activated receptors -PPARs - in glucose control   Massimo Collino and Fausto Chiazza 11. High-fat diets and beta-cell dysfunction: molecular aspects   Carla B. Collares-Buzato 12. Native fruits, anthocyanins in nutraceuticals and the insulin receptor/insulin receptor substrate-1/Akt/ forkhead box protein pathway   N.R.V. Dragano and Anne y Castro Marques 13. Influence of dietary factors on gut microbiota: role on insulin resistance and diabetes mellitus   Gemma Xifra Villarroya, Eduardo Esteve and J.M Fernandez-Real 14.  Molecular aspects of Glucose regulation of pancreatic beta-cells   Rosa Gasa, Ramon Gomis, Anna Novials and Joan-Marc Servitja 15. Metals and signalling in diabetes   Lu Cai 16. Cocoa flavonoids and insulin signalling    Sonia Ramos, M.A. Martin and Luis Goya 17. Dietary proanthocyanidin modulation of pancreatic beta-cells: molecular aspects   Montserrat Pinent, Mayte Blay, Anna Ardevol and Noemi Gonzalez-Abuin 18. Dietary whey protein and Type 2 diabetes: molecular aspects   Jaime Amaya-Farfan, Priscila Neder Morato, Carolina Soares Moura and Pablo Lollo 19. Dietary fatty acids and C-reactive proteins in diabetes   Giovanni Annuzzi, Ettore Griffo, Giuseppina Costabile and Lutgarda Bozzetto 20. Alcoholic beverage and diabetes: cellular and molecular effects   Suzanne de la Monte 21. Nutrition during development and risk of type 2 diabetes   Sjurdur F. Olsen Section 3: Genetic machinery and its function 22. Diabetes and telomers   M Balasubramanyan 23. Alleles and risk of diabetes   Valeriya Lyssenko 24. Micro RNAs in diabetes   Louise Torp Dalgaard, Sofia Anna Salö, Anja Elaine Sørensen and Julian Geiger 25. Genes encoding C-reactive protein and diabetes   Eugenia Flores-Alfaro and Miguel Cruz 26. Diabetes mellitus and intestinal Niemann-Pick C1-Like1 gene expression   W. A. Alrefai, Pooja Malhotra, Ravinder K. Gill and Pradeep K. Dudeja 27. Dietary long-chain omega-3 polyunsaturated fatty acids and inflammatory gene expression in type 2 diabetes   Manohar Lal Garg 28. Polymorphisms, carbohydrates, fat and type 2 diabetes: the example of insulin receptor substrate 1 (IRS1)   Jose Lopez-Miranda 29. Genetic basis linking variants for diabetes and obesity with breast cancer   Vijay Kumar Kutala 30. Genetic determinants of pathways underlying 25(OH) vitamin D deficiency predisposing to  type 1 and type 2 diabetes mellitus   Dharambir K. Sanghera and Piers R. Blackett 31. Genome-wide association: type 2 diabetes susceptibility   Inga Prokopenko 32. Arterial Bone Morphogen Signaling In Diabetic Vascular Disease   Dwight Arnold Towler 33. NRF2-mediated gene regulation and glucose homeostasis   Masayuki Yamamoto and Akira Uruno 34. Hepatic mitochondrial fatty acid oxidation and type 2 diabetes   Abdelhak Mansouri, Wolfgang Langhans, Jean Girard and Carina Prip-Buus 35. The wnt signaling pathway and glucose homeostasis   T. Jin 36. Amino acids and insulin sensitivity: role of hepatic insulin receptor substrate (IRS) and protein kinase B (Akt)genes   Xuefeng Yang

• ISBN: 978-0-12-801585-8
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 01/12/2015
• Nº Volúmenes: 1
• Idioma: Inglés