Hormesis: a revolution in biology, toxicology and medicine

This book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment. This book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, andpharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders. Groundbreaking coverage of an oft experienced, but poorly understoodphenomenon that affects all forms of life on earth Explains why the principleof hormesis is important to our health, our environment, and the future of our planet Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems Illustrates how disorders suchas diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of newdrugs and dietary formulations INDICE: What is Hormesis and Why Does it Matter?.- The Biphasic Dose Response in Toxicology and Environmental Policy.- The Fundamental Role of Hormesis in Evolution.- Protein Chaperones and the Adaptive Stress Response.- Transcriptional Mediators of Cellular Hormesis.- Exercise Hormesis.- Diet, Hormesis andHealth.- Hormesis and Aging.- Couch Potato: the Antithesis of Hormesis.- DrugDevelopment and Hormesis.- The Future of Hormesis in Biomedical Research and Health Care.

• ISBN: 978-1-60761-494-4
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 352
• Fecha Publicación: 01/12/2009
• Nº Volúmenes: 1
• Idioma: Inglés