Developmental and Fetal Origins of Differences in Monozygotic twins: From Genetics to Environmental Factors

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Non random X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout. Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical managementDiscusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysisFeatures contributions from international experts in twin genetics and developmental biology INDICE: 1. The generation of MZ twins 2. Overview on the differences in MZ twins 3. Selective FGR in MZ twins 4. Differences in hemoglobin levels /TAPS 5. Epigenetics and differences in MZ twins 6. NIPT in MZ twins: does it spot the difference? 7. Placentation in MZ twins 8. Differences in amniotic fluid /TTTS 9. Differences in fetal heart in MZ twins 10. Management of discordant anomalies in MZ twins 11. TRAP sequence 12. The new imaging in MZ twins 13. Heterokaryotypic twins 14. Forensic issues in MZ twins 15. The importance of diet in MZ twins 16. Future directions in research of MZ twins

• ISBN: 978-0-12-820047-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 368
• Fecha Publicación: 31/05/2020
• Nº Volúmenes: 1
• Idioma: Inglés