The Neuroscience of Zika Virus

Zika Virus Biology, Transmission, and Pathology: The Neuroscience of Zika provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers' understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions. Zika Virus Impact, Diagnosis, Control, and Models: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barré syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions. Zika Virus Biology, Transmission, and Pathology: Presents the most comprehensive coverage of a broad range of topics related to the neuroscience of Zika, including transmission and virus biology Contains an abstract, key facts, a mini dictionary of terms, and summary points to aid in understanding in each chapter Features chapters on Zika vectors and fetal imaging Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Puerto Rico and India Discusses unique topics in Zika biology, associated neuro-inflammation, and impacts on neurological systems Zika Virus Impact, Diagnosis, Control, and Models: Provides a broad range of topics related to the neuroscience of Zika, including its diagnosis, vaccines and therapy Contains chapter abstracts, key facts, a dictionary of terms and summary points to aid in understanding Discusses novel and non-pharmacological therapies, Guillain-Barré Syndrome and vaccine development Features chapters on rat, mouse, and guinea pig models of Zika and case reports of Zika co-infection with chikungunya, dengue-2 and Guillain-Barré Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Honduras, Uganda, Jamaica and Mozambique INDICE: Zika Virus Biology, Transmission, and Pathology: Section 1 - Zika Virus: Introductory Chapters 1. Flaviviruses and where the Zika virus fits in: An overview Prof. L.A. Diaz, Laboratorio de Arbovirus, Instituto de Virologia Dr. J. M. Vanella, Universidad Nacional de Cordoba, Cordoba, Argentina 2. The Zika virus: A brief overview Prof. A.R. Plourde, University of California San Francisco, Departments of Pathology and Laboratory Medicine, San Francisco, CA, United States 3. The public health perspective of Zika virus-infection Prof. S.R. Shrivastava, Department of Community Medicine, Shri Sathya Sai Medical College and Research Institute, Tamil Nadu, India 4. Zika virus as a potential pandemic Prof. C.J. Carlson, Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA 5. Zika virus, symptomatic and asymptomatic travellers Prof. R. Huits, Institute for Tropical Medicine, Antwerpen, Belgium 6. Microcephaly: features, and impact Prof. A. Steele, Data Resources Program, Bureau of Maternal Child Health, Division of Family Health and Preparedness, Utah Department of Health, Salt Lake City, UT, USA 7. Microcephaly and Zika virus: a short and focused overview Prof. S. Jayakumari, School of Pharmaceutical Sciences, Vels University, Vels Institute of Science, Technology and Advanced Studies [VISTAS], Pallavaram, Chennai, Tamilnadu, India 8. Guillain-Barré Syndrome and Zika viral infections Prof. A.P.Y. Chiu, Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong 9. Non neurological effects of Zika virus infection Prof. F.G. Naveca, Programa de Pos-Graduacao em Imunologia Basica e Aplicada, Universidade Federal Do Amazonas, Manaus Amazonas, Brazil 10. Guillain-Barré syndrome Prof. C.A. Gold, University of California, Department of Neurology, San Francisco, CA, USA 11. Quality of life in mothers of children with microcephaly Prof. P.R.S. Martins-Filho, Universidade Federal de Sergipe, Hospital Universitario, Laboratorio de Patologia Investigativa, Aracaju, Brazil Section 2 - Impact on Neurological Systems 12. Zika virus, immunobiology and autoimmune neurological syndromes in Calcutta Prof. J.-M. Anaya, Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia 13. Impact on Zika virus on paralysis and neuro-inflammation: Jamacian aspects Prof. R. Melbourne-Chambers, Department of Child and Adolescent Health, Faculty ofMedical Sciences, The University of theWest Indies, Jamaica 14. Linking Guillain-Barré and Zika virus infection Prof. A. Ganguly, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh 15. Puerto Rico aspects: Linking Zika virus infection and Guillain-Barré syndrome Prof. E. Dirlikov, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention, San Juan, Puerto Rico 16. Zika virus infection and cytokines Prof. H.I. Nakaya, Department of Pathophysiology and Toxicology, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil 17. Linking microRNAs, Wnt signaling pathway and Zika virus Prof. A.J. Hirsch, Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA 18. Neuronal conduction in Guillain-Barre syndrome Prof. A. Uncini, Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio', Chieti-Pescara, Italy 19. Features of Guillain-Barré syndrome with or without Zika virus Prof. A. Uncini, Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio', Chieti-Pescara, Italy 20. Auditory brainstem in Zika virus infection Prof. V.V. Lazarev, Laboratory of Neurobiology and Clinical Neurophysiology, National Institute of Women, Children and Adolescents, Health Fernandes Figueira, Oswaldo Cruz Foundation (FIOCRUZ), Ministry of Health, Rio de Janeiro, Brazil 21. Neurology without microcephaly in Zika virus Prof. H.C. Ferreira, Department of Physical Therapy, School of Medicine, Universidade Federal Do Rio de Janeiro (UFRJ), Program in Perinatal Health Care, Maternidade Escola, Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil 22. Neurologic manifestations, Zika virus and the adult brain Prof. O.J.M. Do Nascimento, Neurology Department, Universidade Federal Fluminense, Rua Siqueira Campos, Copacabana, Rio de Janeiro, Brazil 23. Infantile Spasms in offspring due to maternal Zika virus Prof. J.G.B. Alves, Department of Paediatrics Neurology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, Brazil 24. Encephalomyelitis and Zika virus infection Prof. W. Roth, Department of Neurology, Columbia University Medical Center, NY, USA 25. Cerebrospinal fluid in microcephaly of Zika virus Prof. C.L. Ramos, Bahiana School of Medicine, Bahiana Foundation for Science Development, Avenida Santa Luzia, Horto Florestal, Salvador, Bahia, Brazil 26. The developing neocortex in Zika virus infection Prof. A.D. Baffet, Institut Curie, PSL Research University, Paris, France 27. Glial cell development and Zika virus Prof. Z. Xu, State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 28. Myelination, microcephaly and Zika virus Prof. M. De Fatima Vasco Aragao, Centro Diagnostico Multimagem, Pernambuco, Brazil 29. Neuronal apoptosis in congenital Zika virus infection Prof. C.-Y. Ho, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA 30. Zika virus and fetal imaging Prof. C. Gutierrez-Marquez, Department of Radiology, Cedimed, Universidad Pontificia Bolivariana, Medellin, Colombia 31. PET Imaging and neuroinflammation in Zika Virus-Infection Prof. T.M. Bocan, Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA 32. Neonatal brain magnetic resonance and normocephalics in Zika virus infection Prof. S.B. Mulkey, Children's National Health System, Division of Fetal and Transitional Medicine, Washington, DC, USA 33. Zika virus and adult human brain structure Prof. R. Bido-Medina, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA Section 3 - Features of the Virus and Transmission 34. Zika virus and codon usage bias Prof. J. Cristina, Laboratorio de Virologia Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay 35. Comparing Zika virus transmission with other viruses: Chikungunya virus Prof. J. Riou, Sorbonne Universites, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique (IPLESP UMRS 1136), Paris, France 36. Vectors of Zika virus transmission: Asian Tiger Mosquito (Aedes albopictus Prof. F. Shabani, School of Environmental and Rural Science, University of New England, Armidale, NSW, Australia 37. Linking Zika virus, dengue virus and modes of transmission Prof. P.F.P. Pimenta, Instituto Rene Rachou, Belo Horizonte, Minas Gerais CEP, Brazil 38. Breast milk and mother-to-child transmission Prof. A.E. Paniz-Mondolfi, Department of Infectious Diseases and Tropical Medicine, Instituto Diagnostico Barquisimeto, IDB Biomedical Research Institute, con Av. La Montanita, Las Mercedes, Cabudare, Venezuela 39. Zika virus due to sexual transmission Prof. A. Bartoloni, Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita degli Studi di Firenze, Florence, Italy Zika Virus Impact, Diagnosis, Control, and Models: Section 1 - Methods, Biomarkers, and Diagnosis 1. Imaging Zika virus infection Prof. S.M. Horner, Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA 2. Use of CRISPR: applications to flaviviruses Prof. J.E. Carette, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA 3. Methods of investigating neurotoxicity of larvicides: applications of systems biology Prof. P. Grandjean, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA 4. Methods for the detection of Zika virus infectivity Prof. A. Marcello, Molecular Virology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy Section 2 - Vector Control, Vaccines, Pharmacology 5. Vector control and Zika virus: a focus on mosquitoes Prof. R. Barrera, Entomology and Ecology Team, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico 6. Vector control: a focus on rural household containers: applications to Zika virus Prof. H.J. Overgaard, Faculty of Science and Technology, Norwegian University of Life Sciences, As, Norway 7. Zika virus Vaccines: an overview Prof. X. Xie, Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA 8. Novel treatment with 2,8-bis(trifluoromethyl)quinoline analogs in Zika infection in vitro Prof. M.V.N. de Souza, Instituto de Tecnologia em Farmacos - Far-Manguinhos, Fiocruz - Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil 9. Zika virus use of human neutralizing antibody in microcephaly prevention: a modelling system Prof. Z. Xu, Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing, China 10. Policies on Zika virus Control Prof. A.P. Galvani, Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, Yale University, New Haven, CT, USA Section 3 - Novel and Non-Pharmacologic Therapies 11. Role of the pediatric neurologist in treating Zika virus syndrome Prof. D.I. Zafeiriou, 1st Department of Pediatrics, Aristotle University, Thessaloniki, Greece 12. 25-Hydroxycholesterol usage in Zika Virus Infection Prof. B.G. Novitch, Department of Neurobiology and Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA 13. Screening and inhibition of the flavivirus NS2B-NS3 protease: application to zika virus Prof. H. Li, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY, USA 14. Gene silencing and applications to zika virus Prof. M.A. Hashem, Department of Biochemistry and Biotechnology, University of Science and Technology Chittagong (USTC), Bangladesh 15. Screening phytochemicals that react against Zika virus Prof. W.N. Setzer, Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA Section 4 - Models and Modelling 16. Guinea pig model of Zika virus: features and applications Prof. M. Kumar, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA 17. Rat model of Zika virus: features and applications Prof. P. Despres, Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Universite de La Reunion, Platform CYROI, Sainte-Clotilde, La Reunion, France 18. Mouse model of Zika virus: features and applications Prof. M.S. Diamond, Department of Medicine, Washington University, School of Medicine, St. Louis, MO, USA 19. Modelling Zika virus in the USA Prof. S. Merler, Fondazione Bruno Kessler, Trento, Italy 20. Modelling Zika virus infection in laboratory animals: impact on neurological systems Prof. J.R. Clarke, School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Section 5 - Neuroscience of Guillain-Barré Syndrome 21. Severe Guillain-Barré Syndrome Prof. S. Kesici, Pediatric Intensive Care Unit, Dr. Sami Ulus Education and Research Hospital, Ankara, Turkey 22. Plasmablasts, plasma and neurotoxic antibodies in Guillain-Barré syndrome Prof. R. Huizinga, Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands 23. Oxidative stress in Guillain-Barré Syndrome and linkage with neurology Prof. S. Gumusyayla, Faculty of Medicine, Departmant of Neurology, Ankara Yildirim Beyazit University, Ankara, Turkey 24. Neuromuscular effects and rehabilitation in Guillain-Barré syndrome Prof. T. Harbo, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark 25. Post-infectious demyelinating diseases: Guillain-Barré syndrome and beyond Prof. T. Foiadelli, Fondazione IRCCS Policlinico San Matteo, Clinica Pediatrica, V.le Camillo Golgi, Pavia, Italy Section 6 - Neuroscience of Microcephaly 26. Microcephaly and developmental delays Prof. S.H. Yoon, Department of Neurosurgery, Ajou University School of Medicine, Suwon, South Korea 27. Congenital microcephaly: features and risk factors Prof. S.M. Kerr, Slone Epidemiology Center at Boston University, Boston, MA, USA 28. Microcephaly in fetal alcohol syndrome Prof. G.G. Hicks, Regenerative Medicine Program and the Department of Biochemistry & Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada 29. Microcephaly in genetic disorders: the case of MFSD2A and hypomyelination Prof. T. Harel, Department of Genetic and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel 30. Folate metabolism, 5,10-methenyltetrahydrofolate synthetase and microcephaly Prof. L.H. Rodan, Boston Children's Hospital, Boston, MA, USA Section 7 - International Aspects 31. Zika Virus in Honduras Prof. A. Rosales, World Vision, Department of Health, District of Columbia, WA, USA 32. Zika Virus in Uganda Prof. B. Arif, Scientist Emeritus, Laboratory for Molecular Virology, Canada 33. Zika Virus in Jamaica Prof. R. Melbourne-Chambers, Department of Child and Adolescent Health, Faculty of Medical Sciences, The University of theWest Indies, Jamaica 34. Zika virus in Mozambique Prof. E.S. Gudo, Virus Isolation Laboratory, National Institute of Health, Ministry of Health, Maputo, Mozambique 35. Zika virus in Brazil Prof. S.S. Sanabani, Department of Pathology, Hospital das Clinicas, School of Medicine University of Sao Paulo, Sao Paulo, Brazil Section 8 - Case Reports 36. Case reports: Zika and Chikungunya virus infection Prof. S. Kutsuna, Disease Control and Prevention Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan 37. Case reports: Zika virus neuroretinitis Prof. A. Panday, Department of Medicine, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago 38. Case reports: Zika virus infection in Singapore Prof. B.Y. Xu, Sengkang Health, SingHealth, Alexandra Hospital, Department of Family Medicine, Singapore, Singapore 39. Case reports: Coinfection with Zika virus and dengue-2 viruses Prof. N.M. Iovine, Department of Medicine, Division of Infectious Diseases, College of Medicine, FL, USA 40. Case report: Guillain-Barré and Zika virus infection Prof. P.F. Walker, HealthPartners Center for International Health, MN, USA Zika Virus Biology, Transmission, and Pathology: Section 1 - Zika Virus: Introductory Chapters 1. Flaviviruses and where the Zika virus fits in: An overview Prof. L.A. Diaz, Laboratorio de Arbovirus, Instituto de Virologia Dr. J. M. Vanella, Universidad Nacional de Cordoba, Cordoba, Argentina 2. The Zika virus: A brief overview Prof. A.R. Plourde, University of California San Francisco, Departments of Pathology and Laboratory Medicine, San Francisco, CA, United States 3. The public health perspective of Zika virus-infection Prof. S.R. Shrivastava, Department of Community Medicine, Shri Sathya Sai Medical College and Research Institute, Tamil Nadu, India 4. Zika virus as a potential pandemic Prof. C.J. Carlson, Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA 5. Zika virus, symptomatic and asymptomatic travellers Prof. R. Huits, Institute for Tropical Medicine, Antwerpen, Belgium 6. Microcephaly: features, and impact Prof. A. Steele, Data Resources Program, Bureau of Maternal Child Health, Division of Family Health and Preparedness, Utah Department of Health, Salt Lake City, UT, USA 7. Microcephaly and Zika virus: a short and focused overview Prof. S. Jayakumari, School of Pharmaceutical Sciences, Vels University, Vels Institute of Science, Technology and Advanced Studies [VISTAS], Pallavaram, Chennai, Tamilnadu, India 8. Guillain-Barré Syndrome and Zika viral infections Prof. A.P.Y. Chiu, Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong 9. Non neurological effects of Zika virus infection Prof. F.G. Naveca, Programa de Pos-Graduacao em Imunologia Basica e Aplicada, Universidade Federal Do Amazonas, Manaus Amazonas, Brazil 10. Guillain-Barré syndrome Prof. C.A. Gold, University of California, Department of Neurology, San Francisco, CA, USA 11. Quality of life in mothers of children with microcephaly Prof. P.R.S. Martins-Filho, Universidade Federal de Sergipe, Hospital Universitario, Laboratorio de Patologia Investigativa, Aracaju, Brazil Section 2 - Impact on Neurological Systems 12. Zika virus, immunobiology and autoimmune neurological syndromes in Calcutta Prof. J.-M. Anaya, Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia 13. Impact on Zika virus on paralysis and neuro-inflammation: Jamacian aspects Prof. R. Melbourne-Chambers, Department of Child and Adolescent Health, Faculty ofMedical Sciences, The University of theWest Indies, Jamaica 14. Linking Guillain-Barré and Zika virus infection Prof. A. Ganguly, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh 15. Puerto Rico aspects: Linking Zika virus infection and Guillain-Barré syndrome Prof. E. Dirlikov, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention, San Juan, Puerto Rico 16. Zika virus infection and cytokines Prof. H.I. Nakaya, Department of Pathophysiology and Toxicology, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil 17. Linking microRNAs, Wnt signaling pathway and Zika virus Prof. A.J. Hirsch, Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA 18. Neuronal conduction in Guillain-Barre syndrome Prof. A. Uncini, Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio', Chieti-Pescara, Italy 19. Features of Guillain-Barré syndrome with or without Zika virus Prof. A. Uncini, Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio', Chieti-Pescara, Italy 20. Auditory brainstem in Zika virus infection Prof. V.V. Lazarev, Laboratory of Neurobiology and Clinical Neurophysiology, National Institute of Women, Children and Adolescents, Health Fernandes Figueira, Oswaldo Cruz Foundation (FIOCRUZ), Ministry of Health, Rio de Janeiro, Brazil 21. Neurology without microcephaly in Zika virus Prof. H.C. Ferreira, Department of Physical Therapy, School of Medicine, Universidade Federal Do Rio de Janeiro (UFRJ), Program in Perinatal Health Care, Maternidade Escola, Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil 22. Neurologic manifestations, Zika virus and the adult brain Prof. O.J.M. Do Nascimento, Neurology Department, Universidade Federal Fluminense, Rua Siqueira Campos, Copacabana, Rio de Janeiro, Brazil 23. Infantile Spasms in offspring due to maternal Zika virus Prof. J.G.B. Alves, Department of Paediatrics Neurology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, Brazil 24. Encephalomyelitis and Zika virus infection Prof. W. Roth, Department of Neurology, Columbia University Medical Center, NY, USA 25. Cerebrospinal fluid in microcephaly of Zika virus Prof. C.L. Ramos, Bahiana School of Medicine, Bahiana Foundation for Science Development, Avenida Santa Luzia, Horto Florestal, Salvador, Bahia, Brazil 26. The developing neocortex in Zika virus infection Prof. A.D. Baffet, Institut Curie, PSL Research University, Paris, France 27. Glial cell development and Zika virus Prof. Z. Xu, State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 28. Myelination, microcephaly and Zika virus Prof. M. De Fatima Vasco Aragao, Centro Diagnostico Multimagem, Pernambuco, Brazil 29. Neuronal apoptosis in congenital Zika virus infection Prof. C.-Y. Ho, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA 30. Zika virus and fetal imaging Prof. C. Gutierrez-Marquez, Department of Radiology, Cedimed, Universidad Pontificia Bolivariana, Medellin, Colombia 31. PET Imaging and neuroinflammation in Zika Virus-Infection Prof. T.M. Bocan, Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA 32. Neonatal brain magnetic resonance and normocephalics in Zika virus infection Prof. S.B. Mulkey, Children's National Health System, Division of Fetal and Transitional Medicine, Washington, DC, USA 33. Zika virus and adult human brain structure Prof. R. Bido-Medina, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA Section 3 - Features of the Virus and Transmission 34. Zika virus and codon usage bias Prof. J. Cristina, Laboratorio de Virologia Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay 35. Comparing Zika virus transmission with other viruses: Chikungunya virus Prof. J. Riou, Sorbonne Universites, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique (IPLESP UMRS 1136), Paris, France 36. Vectors of Zika virus transmission: Asian Tiger Mosquito (Aedes albopictus Prof. F. Shabani, School of Environmental and Rural Science, University of New England, Armidale, NSW, Australia 37. Linking Zika virus, dengue virus and modes of transmission Prof. P.F.P. Pimenta, Instituto Rene Rachou, Belo Horizonte, Minas Gerais CEP, Brazil 38. Breast milk and mother-to-child transmission Prof. A.E. Paniz-Mondolfi, Department of Infectious Diseases and Tropical Medicine, Instituto Diagnostico Barquisimeto, IDB Biomedical Research Institute, con Av. La Montanita, Las Mercedes, Cabudare, Venezuela 39. Zika virus due to sexual transmission Prof. A. Bartoloni, Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita degli Studi di Firenze, Florence, Italy Zika Virus Impact, Diagnosis, Control, and Models: Section 1 - Methods, Biomarkers, and Diagnosis 1. Imaging Zika virus infection Prof. S.M. Horner, Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA 2. Use of CRISPR: applications to flaviviruses Prof. J.E. Carette, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA 3. Methods of investigating neurotoxicity of larvicides: applications of systems biology Prof. P. Grandjean, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA 4. Methods for the detection of Zika virus infectivity Prof. A. Marcello, Molecular Virology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy Section 2 - Vector Control, Vaccines, Pharmacology 5. Vector control and Zika virus: a focus on mosquitoes Prof. R. Barrera, Entomology and Ecology Team, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico 6. Vector control: a focus on rural household containers: applications to Zika virus Prof. H.J. Overgaard, Faculty of Science and Technology, Norwegian University of Life Sciences, As, Norway 7. Zika virus Vaccines: an overview Prof. X. Xie, Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA 8. Novel treatment with 2,8-bis(trifluoromethyl)quinoline analogs in Zika infection in vitro Prof. M.V.N. de Souza, Instituto de Tecnologia em Farmacos - Far-Manguinhos, Fiocruz - Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil 9. Zika virus use of human neutralizing antibody in microcephaly prevention: a modelling system Prof. Z. Xu, Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing, China 10. Policies on Zika virus Control Prof. A.P. Galvani, Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, Yale University, New Haven, CT, USA Section 3 - Novel and Non-Pharmacologic Therapies 11. Role of the pediatric neurologist in treating Zika virus syndrome Prof. D.I. Zafeiriou, 1st Department of Pediatrics, Aristotle University, Thessaloniki, Greece 12. 25-Hydroxycholesterol usage in Zika Virus Infection Prof. B.G. Novitch, Department of Neurobiology and Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA 13. Screening and inhibition of the flavivirus NS2B-NS3 protease: application to zika virus Prof. H. Li, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY, USA 14. Gene silencing and applications to zika virus Prof. M.A. Hashem, Department of Biochemistry and Biotechnology, University of Science and Technology Chittagong (USTC), Bangladesh 15. Screening phytochemicals that react against Zika virus Prof. W.N. Setzer, Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA Section 4 - Models and Modelling 16. Guinea pig model of Zika virus: features and applications Prof. M. Kumar, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA 17. Rat model of Zika virus: features and applications Prof. P. Despres, Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Universite de La Reunion, Platform CYROI, Sainte-Clotilde, La Reunion, France 18. Mouse model of Zika virus: features and applications Prof. M.S. Diamond, Department of Medicine, Washington University, School of Medicine, St. Louis, MO, USA 19. Modelling Zika virus in the USA Prof. S. Merler, Fondazione Bruno Kessler, Trento, Italy 20. Modelling Zika virus infection in laboratory animals: impact on neurological systems Prof. J.R. Clarke, School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Section 5 - Neuroscience of Guillain-Barré Syndrome 21. Severe Guillain-Barré Syndrome Prof. S. Kesici, Pediatric Intensive Care Unit, Dr. Sami Ulus Education and Research Hospital, Ankara, Turkey 22. Plasmablasts, plasma and neurotoxic antibodies in Guillain-Barré syndrome Prof. R. Huizinga, Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands 23. Oxidative stress in Guillain-Barré Syndrome and linkage with neurology Prof. S. Gumusyayla, Faculty of Medicine, Departmant of Neurology, Ankara Yildirim Beyazit University, Ankara, Turkey 24. Neuromuscular effects and rehabilitation in Guillain-Barré syndrome Prof. T. Harbo, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark 25. Post-infectious demyelinating diseases: Guillain-Barré syndrome and beyond Prof. T. Foiadelli, Fondazione IRCCS Policlinico San Matteo, Clinica Pediatrica, V.le Camillo Golgi, Pavia, Italy Section 6 - Neuroscience of Microcephaly 26. Microcephaly and developmental delays Prof. S.H. Yoon, Department of Neurosurgery, Ajou University School of Medicine, Suwon, South Korea 27. Congenital microcephaly: features and risk factors Prof. S.M. Kerr, Slone Epidemiology Center at Boston University, Boston, MA, USA 28. Microcephaly in fetal alcohol syndrome Prof. G.G. Hicks, Regenerative Medicine Program and the Department of Biochemistry & Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada 29. Microcephaly in genetic disorders: the case of MFSD2A and hypomyelination Prof. T. Harel, Department of Genetic and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel 30. Folate metabolism, 5,10-methenyltetrahydrofolate synthetase and microcephaly Prof. L.H. Rodan, Boston Children's Hospital, Boston, MA, USA Section 7 - International Aspects 31. Zika Virus in Honduras Prof. A. Rosales, World Vision, Department of Health, District of Columbia, WA, USA 32. Zika Virus in Uganda Prof. B. Arif, Scientist Emeritus, Laboratory for Molecular Virology, Canada 33. Zika Virus in Jamaica Prof. R. Melbourne-Chambers, Department of Child and Adolescent Health, Faculty of Medical Sciences, The University of theWest Indies, Jamaica 34. Zika virus in Mozambique Prof. E.S. Gudo, Virus Isolation Laboratory, National Institute of Health, Ministry of Health, Maputo, Mozambique 35. Zika virus in Brazil Prof. S.S. Sanabani, Department of Pathology, Hospital das Clinicas, School of Medicine University of Sao Paulo, Sao Paulo, Brazil Section 8 - Case Reports 36. Case reports: Zika and Chikungunya virus infection Prof. S. Kutsuna, Disease Control and Prevention Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan 37. Case reports: Zika virus neuroretinitis Prof. A. Panday, Department of Medicine, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago 38. Case reports: Zika virus infection in Singapore Prof. B.Y. Xu, Sengkang Health, SingHealth, Alexandra Hospital, Department of Family Medicine, Singapore, Singapore 39. Case reports: Coinfection with Zika virus and dengue-2 viruses Prof. N.M. Iovine, Department of Medicine, Division of Infectious Diseases, College of Medicine, FL, USA 40. Case report: Guillain-Barré and Zika virus infection Prof. P.F. Walker, HealthPartners Center for International Health, MN, USA

• ISBN: 978-0-323-85864-9
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 650
• Fecha Publicación: 25/06/2021
• Nº Volúmenes: 1
• Idioma: Inglés