Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasivedisease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research. Comprehensive and critical evaluation of the multiple roles that molecular medicine plays in HF Provides a definitive sense of future approaches in which molecular medicine might further be applied Presents thorough discussions on molecular, cellular and metabolic changes occurring in HF INDICE: Introduction to Heart Failure.- Cardiac Function in Heart Failure:The Role of Calcium Cycling.-Gene Profiling of the Failing Heart -Epigenetics.- Bioenergetics and Metabolic Changes in the Failing Heart.- The Multidimensional Role of Mitochondria in Heart Failure.- Animal Models of Heart Failure.- Signaling Cascades in Heart Failure: >From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways.- Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure.- Calcium Signaling. Receptors, Effectors and other Signaling Pathways.- Oxidative Stress and Heart Failure.- Remodeling and Cellular Death in the Failing Heart.- Heart failure and changes at the periphery: Vascular, Inflammation, Neurohormonal and Renal systems.- Comorbidities in Heart Failure.- Mechanisms and Clinical Recognition and Management of Heart Failure in Infants and Children.- Mechanical Circulatory Support and Heart Transplantation in Children with Severe Refractory Heart Failure.- Basic Mechanisms Mediating Cardiomyopathy and Heart Failing in Aging.- Heart Failure of Aging. Clinical Considerations.- Diagnosis of Heart Failure. Evidence-Based Perspective.- 'Omics' Application in Heart Failure: Novel Diagnostic and Prognostic Markers to Understand Pathophysiology and Finding New Therapies.- Treatment of Chronic Heart Failure.- Gene Therapy inHeart Failure: Forthcoming Therapies.- Myocardial Cell-Based Regeneration in Heart Failure.- Future Frontiers in Heart Failure
- ISBN: 978-1-60761-146-2
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 850
- Fecha Publicación: 18/07/2010
- Nº Volúmenes: 1
- Idioma: Inglés