Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation. Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, celladhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis,and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. A unique book dedicated to breast cancer metastasis Indepth coverage of the biology of metastasis Hot topics in new markers and diagnosis Micro-metastasis and sentinel node therapies Current management of metastatic breast cancer INDICE: From the contents 1: Metastasis of breast cancer, an introduction.- 2: The genetic control of breast cancer metastasis.- 3: BRCA1 in initiation,invasion and metastasis of breast cancer: a perspective from the tumor microenvironment.- 4: Cell motility and breast cancer metastasis.- 5: Tight junctions and metastasis of breast cancer.- 6: Cell adhesion molecules in breast cancer invasion and metastasis.- 7: Endocrine resistance and breast cancer invasion.- 8: The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis.- 9: The role of the HGF regulatory factors in breast cancer.- 10: The insulin-like growth factor-1 ligand in breast cancer management.
- ISBN: 978-1-4020-8529-1
- Editorial: Springer
- Encuadernacion: Rústica
- Páginas: 432
- Fecha Publicación: 01/06/2008
- Nº Volúmenes: 1
- Idioma: Inglés