The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics. INDICE: Chapter 1: An overview on Transcription by RNA polymerase II . Michael Hampsey. Professor and Chairman, Department of Biochemistry,. University of Medicine and Dentistry of New Jersey, USA. . Chapter 2: Chromatin Structure, Histone Modification and Histone Code. Michael Cosgrove. Associate Professor, Department of Biochemistry and Molecular Biology . SUNY Upstate Medical University, New York. . Chapter 3: Chromatin Remodelling. Geetha Narlikar. Associate Professor, Biochemistry and Biophysics. University of California San, USA. . Chapter 4: Histone Methylation, Demethylation and Gene Regulation . Sukesh Bhaumik. Associate Professor, Department of Biochemistry. Southern Illinois University Medical School, USA. . Chapter 5: Histone Acetylation and Deacetylation and Gene Regulation. Alejandro Vaquero. Group Leader, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute . Barcelona, Spain. . Chapter 6: Non–coding RNAs in gene regulation and disease. Deepak Srivastava. Professor, Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA. . Chapter 7: X–inactivation. Jeffery Demuth, . Assistant Professor, Department of Biology,. University of Texas at Arlington, USA. . Chapter 8: Histone variants: Structure, function and implication in disease. Alejandra Loyola. Assistant Professor, Fundación Ciencia para la Vida, Santiago 7780272, Chile. . Chapter 9: Centromere Organization, Kinetochore Assembly and chromosome segregation . Xiangwei He. Associate Professor. University of Texas at Austin, USA. . Chapter 10: DNA methylation and epigenetics . J Bender. Professor, Department of Biochemistry and Molecular Biology, . Johns Hopkins University, Maryland, USA. . . Chapter 11: Genomic Imprinting. Elena de la Casa–Esperón. Principal Investigator. School of Farmacy, University of Castilla–La Mancha, Spain. . Chapter 12: Hypoxia Signaling, Angiogenesis, Tumor microenvironment and Epigenetics . J Bussink . Professor, Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. . Chapter 13: Epigenetics and stem cells. Sendurai A. Mani. Assistant Professor, Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. . Chapter 14: Trends in epigenetic drug targets and cancer therapy. Sanjay Awasthi, MD. Professor, Diabetes, Metabolism & Endocrinology, City of Hope in Duarte, California. . Chapter 15: Endocrine signaling, Nuclear Receptors, NR–Coregulators and Human Disease. Subhrangsu Mandal . Associate Professor, University of Texas at Arlington, USA. . Chapter 16: Estrogen and progesterone signaling and action, . Linda Perrotti. Assistant Professor of Psychology, University of Texas at Arlington, USA. . Chapter 17: Estrogen Signaling and Neuroprotection. James Simpkins. Professor, Department of Pharmacology and Neuroscience, . University of North Texas Health Science Center, Fort Worth, USA. . Chapter 18: Gluocorticoid Receptor Mediated Signaling and Stress Metabolism. Rosalie Uht. Associate Professor, Department of Pharmacology and Neuroscience,. University of North Texas Health Science center–Fort Worth, USA. . Chapter 19: Androgen Signaling and Prostate cancer . Ganesh Raj, MD. Professor, Department of Urology,. University of Texas Southwestern Medical Center–Dallas, USA. . Chapter 20: PPARs and Adipogenesis . Medina–Gomez G. Professor, Department of Clinical Biochemistry and Medicine, University of Cambridge, UK . . Chapter 21: RAR/RXR Mediated Signaling . Jörg Mey. Professor, Institute of Biology II, RWTH Aachen University, Germany. . Chapter 22: Hormones, Epigenetic and Developmental Programming . Abigail L. Fowden. Professor, University of Cambridge, UK. . Chapter 23: Endocrine Disruption: Mechanism of Action, Developmental Defects and Disease. John A. McLachlan. Professor of Pharmacology, Professor of Ecology & Evolutionary, Tulane, University, USA. . Chapter 24: Endocrine Disruption: Environment and wild life. CR Tyler. Professor, Department of Biology and Biochemistry, Brunel University, UK.
- ISBN: 978-3-527-32281-7
- Editorial: Wiley VCH
- Encuadernacion: Cartoné
- Páginas: 668
- Fecha Publicación: 21/06/2017
- Nº Volúmenes: 1
- Idioma: Inglés